Transcription Factor

						

			
Accessions: 4lln_D (3D-footprint 20231221)

			
Names: MarR family HTH-type transcriptional regulator mepR, MarR family regulatory protein, MarR family transcriptional regulator, MepA/mepB repressor and autoregulator, MepR, Multidrug efflux MATE transporter transcriptional repressor MepR, Multidrug efflux transporter transcriptional repressor MepR, Q5Y812_STAAU, Transcriptional regulator SlyA, Transcriptional regulator, MarR family
Organisms: Staphylococcus aureus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q5Y812
Length: 139
Pfam Domains:     29-88 MarR family
    31-96 Winged helix DNA-binding domain
    31-88 MarR family
    45-78 Winged helix-turn-helix DNA-binding
Sequence: 
(in bold interface residues)		   1 SNEFTYSYLFRMISHEMKQKADQKLEQFDITNEQGHTLGYLYAHQQDGLTQNDIAKALQR   60
  61 TGPTVSNLLRNLERKKLIYRYVDAQDTRKNIGLTTSGIKLVEAFTSIFDEMEQTLVSQLS  120
 121 EEENEQMKANLTKMLSSLQ
Interface Residues: 52, 61, 62, 63, 64, 66, 67, 70, 71, 88
3D-footprint Homologues: 7el3_B, 5k98_B, 3dnv_B, 6fix_D, 1f5t_A, 4lln_I, 7dvv_A, 1u8r_B, 2isz_B, 1ddn_B, 5hlg_E
Binding Motifs: 4lln_CD TTAGAnnTsTAAnnA
Binding Sites: 4lln_E / 4lln_F
			
Publications: Birukou I, Seo S.M, Schindler B.D, Kaatz G.W, Brennan R.G. Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR. Nucleic acids research 42:2774-88 (2014). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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