Transcription Factor

						

			
Accessions: NFATC3 (HT-SELEX2 May2017)

			
Names: ENSG00000072736, NFATC3
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: RHD_IPT experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: RHD_IPT experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3
Length: 323
Pfam Domains:    39-198 Rel homology domain (RHD)
  206-303 IPT/TIG domain
Sequence: 
(in bold interface residues)		   1 VPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPAHFGQCELKIEVQPKTHHRAHYETEGSRG   60
  61 AVKASTGGHPVVKLLGYNEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEII  120
 121 IASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQ  180
 181 PSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFL  240
 241 EKGQDGRPQWEVEGKIIREKCQGAHIVLEVPPYHNPAVTAAVQVHFYLCNGKRKKSQSQR  300
 301 FTYTPVLMKQEHREEIDLSSVPS
Interface Residues: 50, 52, 53, 55, 56, 59, 148, 165, 199, 200, 201, 230, 262, 292, 293
3D-footprint Homologues: 2ram_A, 1imh_C, 1p7h_L, 2o61_A, 1a66_A, 7cli_B, 1a3q_A, 8g00_J
Binding Motifs: NFATC3_4 aryGGAAAmw
NFATC3_5 kTTTCCATGGAAAm
NFATC3_6 ryGGAAAmwtkawkTTTCCry
NFATC3_methyl_1 aryGGAAAmw
NFATC3_methyl_2 kTTTCCryGGAAAm
NFATC3_methyl_3 ryGGAAAmwtsawkTTTCCry
			
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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