Transcription Factor
| Accessions: | 6wc5_N (3D-footprint 20231221) |
| Names: | Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Homeobox protein Nkx-2.5, NKX25_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P52952 |
| Length: | 55 |
| Pfam Domains: | 1-55 Homeobox domain |
| Sequence: (in bold interface residues) | 1 KPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKSK |
| Interface Residues: | 1, 2, 3, 41, 42, 44, 45, 48, 49, 52, 53 |
| 3D-footprint Homologues: | 6m3d_C, 2lkx_A, 1nk2_P, 1zq3_P, 6es3_K, 2ld5_A, 7q3o_C, 2h1k_B, 1b72_A, 4xrs_G, 1puf_A, 1ig7_A, 5zfz_A, 3a01_E, 5flv_I, 3lnq_A, 1jgg_B, 5zjt_E, 3cmy_A, 2hdd_A, 7psx_B, 5hod_A, 3rkq_B, 2r5y_A, 6a8r_A, 1au7_A, 3d1n_M, 2hos_A, 1fjl_B, 5jlw_D, 4cyc_A, 1le8_A, 7xrc_C, 4j19_B, 2h8r_B, 1e3o_C, 2xsd_C, 3l1p_A, 1mnm_C, 1du0_A, 1puf_B, 8g87_X, 4qtr_D, 1k61_B, 4xrm_B, 1o4x_A |
| Binding Motifs: | 6wc5_CDN CTTTCynnnnnTAG 6wc5_N CnCTTT |
| Binding Sites: | 6wc5_G 6wc5_H |
| Publications: | Lei X, Zhao J, Sagendorf JM, Rajashekar N, Xu J, Dantas Machado AC, Sen C, Rohs R, Feng P, Chen L. Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J Mol Biol 432:5499-5508 (2020). [Pubmed] |
| Related annotations: | PaperBLAST |
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