Transcription Factor

						

			
Accessions: 1f5t_A (3D-footprint 20231221), 1f5t_B (3D-footprint 20231221), 1f5t_C (3D-footprint 20231221), 1f5t_D (3D-footprint 20231221)

			
Names: DIPHTHERIA TOXIN REPRESSOR, DTXR_CORDI, Iron-dependent diphtheria tox regulatory element, Tox regulatory factor
Organisms: Corynebacterium diphtheriae, strain ATCC 700971 / NCTC 13129 / Biotype gravis
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P0DJL7
Length: 120
Pfam Domains:      2-61 Iron dependent repressor, N-terminal DNA binding domain
   64-119 Iron dependent repressor, metal binding and dimerisation domain
Sequence: 
(in bold interface residues)		   1 KDLVDTTEMYLRTIYELEEEGVTPLRARIAERLEQSGPTVSQTVARMERDGLVVVASDRS   60
  61 LQMTPTGRTLATAVMRKHRLAERLLTDIIGLDINKVHDEADRWEHVMSDEVERRLVKVLK  120
Interface Residues: 26, 36, 37, 38, 39, 40, 41, 42, 43, 46
3D-footprint Homologues: 3jso_B, 2isz_B, 1ddn_B, 1f5t_A, 4lln_I, 1u8r_B, 7b24_C
Binding Motifs: 1f5t_A GGCT
1f5t_ABCD AGGTtAGCCTaACnT
Binding Sites: 1f5t_E
1f5t_F
			
Publications: Chen C.S, White A, Love J, Murphy J.R, Ringe D. Methyl groups of thymine bases are important for nucleic acid recognition by DtxR. Biochemistry 39:10397-407 (2000). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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