Transcription Factor
| Accessions: | MAX_HUMAN (HOCOMOCO 10), P61244 (JASPAR 2024) |
| Names: | bHLHd4, Class D basic helix-loop-helix protein 4, MAX_HUMAN, Myc-associated factor X, Protein max |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 160 |
| Pfam Domains: | 24-74 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASR 60 61 AQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDN 120 121 SLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS |
| Interface Residues: | 25, 27, 28, 29, 31, 32, 35, 36, 40, 60 |
| 3D-footprint Homologues: | 1a0a_B, 7z5k_B, 1an4_A, 7f2f_B, 5eyo_A, 7xq5_A, 5v0l_A, 7rcu_E, 5gnj_I, 6g1l_A, 1am9_A, 7ssa_L, 5i50_B, 8osl_O, 7d8t_A, 7xi3_A, 5nj8_D |
| Binding Motifs: | MA0058.3 amCACGTGcy MA0058.2 rrgCACATGk UN0507.1 aCCGGAAaCACGTGs MAX_HUMAN.H10MO.A|M01314 rryCACGTGst MA0058.1 rrmCACGTGr MA0059.1 rAsCACGTGGt MA0058.4 CACGTG MA0059.2 AsCACGTGGt UN0507.2 CCGGAAaCACGTG |
| Binding Sites: | MA0059.2.6 MA0058.1.1 MA0058.1.10 MA0058.1.11 MA0058.1.12 MA0058.1.13 MA0058.1.14 MA0058.1.15 MA0058.1.16 MA0058.1.17 MA0058.1.2 MA0058.1.3 MA0058.1.4 MA0058.1.5 MA0058.1.6 MA0058.1.7 MA0058.1.8 MA0058.1.9 MA0058.2.1 MA0058.2.10 MA0058.2.11 MA0058.2.12 MA0058.2.13 MA0058.2.14 MA0058.2.15 MA0058.2.16 MA0058.2.17 MA0058.2.18 MA0058.2.19 MA0058.2.2 MA0058.2.20 MA0058.2.3 MA0058.2.4 MA0058.2.5 MA0058.2.6 MA0058.2.7 MA0058.2.8 MA0058.2.9 MA0059.1.1 MA0059.1.10 MA0059.1.11 MA0059.1.12 MA0059.1.13 MA0059.1.14 MA0059.1.15 MA0059.1.16 MA0059.1.17 MA0059.1.18 MA0059.1.19 MA0059.1.2 MA0059.1.20 MA0059.1.3 MA0059.1.4 MA0059.1.5 MA0059.1.6 MA0059.1.7 MA0059.1.8 MA0059.1.9 MA0059.2.3 MA0059.2.1 MA0059.2.10 MA0059.2.11 MA0059.2.12 MA0059.2.13 MA0059.2.14 MA0059.2.15 MA0059.2.16 MA0059.2.17 MA0059.2.18 MA0059.2.19 MA0059.2.2 MA0059.2.20 MA0059.2.4 MA0059.2.5 MA0059.2.7 MA0059.2.8 MA0059.2.9 |
| Publications: | Solomon D. L. C., Amati B., Land H. Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers. Nucleic Acids Res. 21:5372-5376 (1993). [Pubmed] Gerstein MB, Kundaje A, Hariharan M, Landt SG, Yan KK, Cheng C, Mu XJ, Khurana E, Rozowsky J, Alexander R, Min R, Alves P, Abyzov A, Addleman N, Bhardwaj N, Boyle AP, Cayting P, Charos A, Chen DZ, Cheng Y, Clarke D, Eastman C, Euskirchen G, Frietze S, Fu Y, Gertz J, Grubert F, Harmanci A, Jain P, Kasowski M, Lacroute P, Leng J, Lian J, Monahan H, O'Geen H, Ouyang Z, Partridge EC, Patacsil D, Pauli F, Raha D, Ramirez L, Reddy TE, Reed B, Shi M, Slifer T, Wang J, Wu L, Yang X, Yip KY, Zilberman-Schapira G, Batzoglou S, Sidow A, Farnham PJ, Myers RM, Weissman SM, Snyder M. Architecture of the human regulatory network derived from ENCODE data. Nature 489:91-100 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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