Transcription Factor

						

			
Accessions: A2RRD8 (JASPAR 2024)

			
Names: ZN320_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: A2RRD8
Length: 509
Pfam Domains:      8-48 KRAB box
  147-172 Zinc-finger double domain
  160-171 C2H2-type zinc finger
  161-183 Zinc finger, C2H2 type
  161-183 C2H2-type zinc finger
  175-200 Zinc-finger double domain
  188-199 C2H2-type zinc finger
  189-211 Zinc finger, C2H2 type
  189-207 C2H2-type zinc finger
  189-211 Zinc-finger of C2H2 type
  203-227 Zinc-finger double domain
  217-226 C2H2-type zinc finger
  217-239 Zinc finger, C2H2 type
  233-255 Zinc-finger double domain
  244-264 C2H2-type zinc finger
  245-267 Zinc finger, C2H2 type
  245-265 C2H2-type zinc finger
  259-283 Zinc-finger double domain
  272-295 C2H2-type zinc finger
  273-295 Zinc finger, C2H2 type
  273-295 C2H2-type zinc finger
  288-312 Zinc-finger double domain
  300-323 C2H2-type zinc finger
  301-323 C2H2-type zinc finger
  301-323 Zinc finger, C2H2 type
  319-340 Zinc-finger double domain
  329-351 C2H2-type zinc finger
  329-345 C2H2-type zinc finger
  329-351 Zinc finger, C2H2 type
  329-349 Zinc-finger of C2H2 type
  343-367 Zinc-finger double domain
  356-379 C2H2-type zinc finger
  357-379 Zinc finger, C2H2 type
  357-379 C2H2-type zinc finger
  372-396 Zinc-finger double domain
  384-396 C2H2-type zinc finger
  385-407 Zinc finger, C2H2 type
  385-407 C2H2-type zinc finger
  400-422 Zinc-finger double domain
  412-422 C2H2-type zinc finger
  413-435 Zinc finger, C2H2 type
  413-435 C2H2-type zinc finger
  427-451 Zinc-finger double domain
  440-461 C2H2-type zinc finger
  441-463 Zinc finger, C2H2 type
  441-463 C2H2-type zinc finger
  455-479 Zinc-finger double domain
  469-484 C2H2-type zinc finger
  469-489 Zinc finger, C2H2 type
  469-489 C2H2-type zinc finger
Sequence: 
(in bold interface residues)		   1 MALSQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMNTLSS   60
  61 TGQGNTEVIHTGTLQRQASYHIGAFCSQEIEKDIHDFVFQWQEDETNDHEAPMTEIKKLT  120
 121 SSTDRYDQRHAGNKPIKGQLESRFHLHLRRHRRIHTGEKPYKCEECEKVFSCKSHLEIHR  180
 181 IIHTGEKPYKCKVCDKAFKHDSHLAKHTRIHRGDKHYTCNECGKVFDQKATLACHHRSHT  240
 241 GEKPYKCNECGKTFSQTSHLVYHHRLHTGEKPYKCNECGKTFARNSVLVIHKAVHTAEKP  300
 301 YKCNECGKVFKQRATLAGHRRVHTGEKPYRCEECDKVFSRKSHLERHRRIHTGEKPYKCK  360
 361 VCDKAFRSDSRLAEHQRVHTGERPYTCNECGKVFSTKAYLACHQKLHTGEKLYECEECDK  420
 421 VYIRKSHLERHRRIHTGEKPHKCGDCGKAFNSPSHLIRHQRIHTGQKSYKCHQCGKVFSL  480
 481 RSLLAEHQKIPFGDNCFKCNEYSKPSSIN
Interface Residues: 150, 171, 172, 175, 178, 181, 200, 201, 202, 203, 205, 206, 210, 228, 230, 231, 234, 256, 258, 259, 262, 283, 284, 285, 286, 287, 290, 301, 311, 312, 313, 314, 315, 317, 318, 319, 320, 321, 322, 324, 339, 340, 341, 342, 343, 344, 345, 346, 347, 352, 366, 367, 368, 369, 370, 371, 372, 373, 374, 377, 378, 395, 396, 397, 398, 399, 401, 402, 424, 425, 426, 427, 430, 452, 454, 455, 458
3D-footprint Homologues: 7w1m_H, 8ssq_A, 8ssu_A, 2drp_D, 6wmi_A, 7txc_E, 5ei9_F, 6ml4_A, 5v3j_F, 2i13_A, 1llm_D, 5yel_A, 6jnm_A, 1mey_C, 6a57_A, 2kmk_A, 3uk3_C, 1tf3_A, 2gli_A, 1tf6_A, 8gn3_A, 6blw_A, 5kkq_D, 6u9q_A, 4m9v_C, 6e94_A, 7ysf_A, 2jpa_A, 1ubd_C, 7y3l_A, 7n5w_A, 5kl3_A, 1f2i_J, 5yj3_D, 5und_A, 1g2f_F, 5k5l_F, 4x9j_A, 2wbs_A, 8h9h_G, 7eyi_G, 2lt7_A, 8cuc_F, 5k5i_A, 7y3m_I
Binding Motifs: MA1976.1 rGkGGGrcCmrGGGGMmwrtGmgrsks
MA1976.2 GkGGGrcCmrGGGGMmwrtG
			
Publications: Imbeault M, Helleboid PY, Trono D. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. Nature 543:550-554 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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