Transcription Factor
| Accessions: | ZNF684 (HT-SELEX2 May2017), ZNF684 (humanC2H2ZF-ChIP Feb2015), Q5T5D7 (JASPAR 2024) |
| Names: | ENSG00000117010, ZNF684, Q5T5D7, ZN684_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, humanC2H2ZF-ChIP Feb2015 2, JASPAR 2024 3 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: KRAB_Znf_C2H2 experiment: HT-SELEX Hamming distance: 2 cycle: 3, TF family: KRAB_Znf_C2H2 experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 3, TF family: C2H2;KRAB experiment: ChIP-seq/MEME/B1H-RC |
| Length: | 378 |
| Pfam Domains: | 8-48 KRAB box 147-169 Zinc-finger double domain 159-181 Zinc finger, C2H2 type 159-181 C2H2-type zinc finger 159-168 C2H2-type zinc finger 175-197 Zinc-finger double domain 187-209 Zinc finger, C2H2 type 187-209 C2H2-type zinc finger 187-197 C2H2-type zinc finger 201-224 Zinc-finger double domain 215-237 Zinc finger, C2H2 type 215-237 C2H2-type zinc finger 215-237 C2H2-type zinc finger 230-253 Zinc-finger double domain 242-253 C2H2-type zinc finger 243-265 Zinc finger, C2H2 type 243-265 C2H2-type zinc finger 258-281 Zinc-finger double domain 271-293 Zinc finger, C2H2 type 271-291 C2H2-type zinc finger 271-293 C2H2-type zinc finger 285-310 Zinc-finger double domain 299-321 C2H2-type zinc finger 299-319 C2H2-type zinc finger 299-321 Zinc finger, C2H2 type 314-336 Zinc-finger double domain 327-349 Zinc finger, C2H2 type 327-349 C2H2-type zinc finger 341-365 Zinc-finger double domain 354-375 C2H2-type zinc finger 355-377 Zinc finger, C2H2 type 355-377 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MISFQESVTFQDVAVDFTAEEWQLLDCAERTLYWDVMLENYRNLISVGCPITKTKVILKV 60 61 EQGQEPWMVEGANPHESSPESDYPLVDEPGKHRESKDNFLKSVLLTFNKILTMERIHHYN 120 121 MSTSLNPMRKKSYKSFEKCLPPNLDLLKYNRSYTVENAYECSECGKAFKKKFHFIRHEKN 180 181 HTRKKPFECNDCGKAYSRKAHLATHQKIHNGERPFVCNDCGKAFMHKAQLVVHQRLHTGE 240 241 KPYECSQCGKTFTWNSSFNQHVKSHTLEKSFECKECGKTFRYSSSLYKHSRFHTGEKPYQ 300 301 CIICGKAFGNTSVLVTHQRIHTGEKPYSCIECGKAFIKKSHLLRHQITHTGEKPYECNRC 360 361 GKAFSQKSNLIVHQKIHT |
| Interface Residues: | 170, 171, 172, 173, 176, 197, 198, 199, 200, 201, 204, 225, 226, 227, 228, 229, 232, 233, 236, 253, 254, 255, 256, 257, 258, 259, 260, 261, 263, 266, 279, 281, 282, 283, 284, 285, 287, 288, 290, 291, 294, 299, 309, 310, 311, 312, 313, 316, 337, 338, 339, 340, 341, 343, 344, 350, 364, 365, 366, 367, 368, 369, 370, 371, 372, 376 |
| 3D-footprint Homologues: | 8ssu_A, 5v3j_F, 8gn3_A, 2gli_A, 8ssq_A, 7w1m_H, 7eyi_G, 5und_A, 2i13_A, 7y3m_I, 6jnm_A, 5kkq_D, 1g2f_F, 1tf6_A, 7txc_E, 4m9v_C, 6a57_A, 6wmi_A, 4kli_A, 2lt7_A, 6e94_A, 7ysf_A, 5yel_A, 1ubd_C, 4pog_H, 1mey_C, 1f2i_J, 6ml4_A, 6blw_A, 5ei9_F, 5k5i_A, 2jpa_A, 2kmk_A, 1tf3_A, 7n5w_A, 4x9j_A, 6u9q_A, 5kl3_A, 1llm_D, 8h9h_G, 8cuc_F, 3uk3_C, 7y3l_A, 5k5l_F, 2drp_D, 5yj3_D, 2wbs_A |
| Binding Motifs: | MA1600.1 / ZNF684_2 ryACAGTCCACCCCTTkr ZNF684_methyl_1 ryACAGTCCACCCCTTkr ZNF684_ChIP AAGGGGTGGACTGT MA1600.2 ACAGTCCACCCCTT |
| Publications: | Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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