Transcription Factor
| Accessions: | CDX2_MOUSE (HOCOMOCO 10), P43241 (JASPAR 2024) |
| Names: | Caudal-type homeobox protein 2, CDX2_MOUSE, Homeobox protein CDX-2 |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 311 |
| Pfam Domains: | 13-178 Caudal like protein activation region 187-242 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAATANLDSAQS 60 61 PGPSWPTAYGAPLREDWNGYAPGGAAAANAVAHGLNGGSPAAAMGYSSPAEYHAHHHPHH 120 121 HPHHPAASPSCASGLLQTLNLGPPGPAATAAAEQLSPSGQRRNLCEWMRKPAQQSLGSQV 180 181 KTRTKDKYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKE 240 241 RKIKKKQQQQQQQQQQQPPQPPPQPSQPQPGALRSVPEPLSPVTSLQGSVPGSVPGVLGP 300 301 AGGVLNSTVTQ |
| Interface Residues: | 181, 183, 186, 187, 188, 189, 227, 228, 230, 231, 234, 235, 238, 239, 242 |
| 3D-footprint Homologues: | 2lkx_A, 1puf_A, 1zq3_P, 3lnq_A, 1jgg_B, 1nk2_P, 2ld5_A, 7q3o_C, 6es3_K, 4cyc_A, 7psx_B, 1ig7_A, 6a8r_A, 3a01_E, 2h1k_B, 5jlw_D, 4xrs_G, 3cmy_A, 2hdd_A, 5zfz_A, 3rkq_B, 2r5y_A, 6m3d_C, 5flv_I, 2hos_A, 1fjl_B, 5zjt_E, 2xsd_C, 1le8_A, 7xrc_C, 1e3o_C, 1au7_A, 1b72_A, 5hod_A, 3l1p_A, 1o4x_A, 4qtr_D, 1le8_B, 1du0_A, 1mnm_C, 1puf_B, 1k61_B, 3d1n_M, 8g87_X |
| Binding Motifs: | CDX2_MOUSE.H10MO.C|M01029 wTTTAyrr PH0013.1 drvgGymATAAAayky |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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