Transcription Factor
| Accessions: | MZF1 (humanC2H2ZF-ChIP Feb2015), P28698 (JASPAR 2024) |
| Names: | ENSG00000099326, MZF1, P28698, Myeloid zinc finger 1, MZF-1, MZF1_HUMAN, Zinc finger and SCAN domain-containing protein 6, Zinc finger protein 42 |
| Organisms: | Homo sapiens |
| Libraries: | humanC2H2ZF-ChIP Feb2015 1, JASPAR 2024 2 1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P28698 |
| Notes: | TF family: C2H2;SCAN experiment: ChIP-seq/MEME/B1H-RC |
| Length: | 734 |
| Pfam Domains: | 39-132 SCAN domain 357-378 Zinc finger, C2H2 type 357-378 C2H2-type zinc finger 357-376 C2H2-type zinc finger 370-395 Zinc-finger double domain 384-403 C2H2-type zinc finger 384-406 Zinc finger, C2H2 type 384-406 C2H2-type zinc finger 398-422 Zinc-finger double domain 412-434 C2H2-type zinc finger 412-434 Zinc finger, C2H2 type 427-450 Zinc-finger double domain 440-460 C2H2-type zinc finger 440-462 C2H2-type zinc finger 440-462 Zinc finger, C2H2 type 485-507 C2H2-type zinc finger 485-507 C2H2-type zinc finger 485-507 Zinc finger, C2H2 type 500-523 Zinc-finger double domain 514-535 Zinc finger, C2H2 type 515-536 C2H2-type zinc finger 515-535 C2H2-type zinc finger 528-551 Zinc-finger double domain 541-563 C2H2-type zinc finger 541-563 Zinc finger, C2H2 type 541-561 C2H2-type zinc finger 555-579 Zinc-finger double domain 569-591 C2H2-type zinc finger 569-591 Zinc finger, C2H2 type 569-591 C2H2-type zinc finger 584-607 Zinc-finger double domain 597-619 C2H2-type zinc finger 597-619 Zinc finger, C2H2 type 597-619 C2H2-type zinc finger 612-635 Zinc-finger double domain 625-647 C2H2-type zinc finger 640-663 Zinc-finger double domain 653-673 C2H2-type zinc finger 653-675 Zinc finger, C2H2 type 653-675 C2H2-type zinc finger 667-691 Zinc-finger double domain 681-705 C2H2-type zinc finger 681-703 Zinc finger, C2H2 type 681-703 C2H2-type zinc finger 696-719 Zinc-finger double domain 709-732 C2H2-type zinc finger 709-731 Zinc finger, C2H2 type 709-731 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MRPAVLGSPDRAPPEDEGPVMVKLEDSEEEGEAALWDPGPEAARLRFRCFRYEEATGPQE 60 61 ALAQLRELCRQWLRPEVRSKEQMLELLVLEQFLGALPPEIQARVQGQRPGSPEEAAALVD 120 121 GLRREPGGPRRWVTVQVQGQEVLSEKMEPSSFQPLPETEPPTPEPGPKTPPRTMQESPLG 180 181 LQVKEESEVTEDSDFLESGPLAATQESVPTLLPEEAQRCGTVLDQIFPHSKTGPEGPSWR 240 241 EHPRALWHEEAGGIFSPGFALQLGSISAGPGSVSPHLHVPWDLGMAGLSGQIQSPSREGG 300 301 FAHALLLPSDLRSEQDPTDEDPCRGVGPALITTRWRSPRGRSRGRPSTGGGVVRGGRCDV 360 361 CGKVFSQRSNLLRHQKIHTGERPFVCSECGRSFSRSSHLLRHQLTHTEERPFVCGDCGQG 420 421 FVRSARLEEHRRVHTGEQPFRCAECGQSFRQRSNLLQHQRIHGDPPGPGAKPPAPPGAPE 480 481 PPGPFPCSECRESFARRAVLLEHQAVHTGDKSFGCVECGERFGRRSVLLQHRRVHSGERP 540 541 FACAECGQSFRQRSNLTQHRRIHTGERPFACAECGKAFRQRPTLTQHLRVHTGEKPFACP 600 601 ECGQRFSQRLKLTRHQRTHTGEKPYHCGECGLGFTQVSRLTEHQRIHTGERPFACPECGQ 660 661 SFRQHANLTQHRRIHTGERPYACPECGKAFRQRPTLTQHLRTHRREKPFACQDCGRRFHQ 720 721 STKLIQHQRVHSAE |
| Interface Residues: | 366, 367, 369, 370, 373, 377, 395, 397, 398, 401, 423, 424, 425, 426, 429, 450, 451, 452, 453, 454, 457, 496, 497, 498, 499, 502, 506, 523, 524, 526, 527, 530, 552, 554, 555, 558, 562, 569, 579, 580, 581, 582, 583, 585, 586, 588, 589, 592, 607, 608, 609, 610, 611, 614, 617, 635, 636, 637, 638, 639, 641, 642, 645, 648, 662, 663, 664, 665, 666, 667, 670, 671, 673, 674, 691, 692, 693, 694, 695, 696, 697, 698, 699, 719, 720, 722, 723, 726 |
| 3D-footprint Homologues: | 8cuc_F, 7y3l_A, 8gn3_A, 8ssq_A, 8ssu_A, 7y3m_I, 1llm_D, 5kl3_A, 5yj3_D, 7w1m_H, 5v3j_F, 6a57_A, 2i13_A, 5kkq_D, 6u9q_A, 2gli_A, 1g2f_F, 6e94_A, 2kmk_A, 1tf3_A, 6blw_A, 7txc_E, 6wmi_A, 5und_A, 6ml4_A, 5yel_A, 2jpa_A, 7n5w_A, 2wbs_A, 5ei9_F, 1mey_C, 1f2i_J, 5k5i_A, 1tf6_A, 4x9j_A, 8h9h_G, 7eyi_G, 7ysf_A, 1ubd_C, 6jnm_A, 2drp_D, 2lt7_A, 3uk3_C, 4m9v_C, 5k5l_F |
| Binding Motifs: | MZF1_ChIP AAAATGG MA0056.1 yGGGGA MA0057.1 bkAKGGGkrr MA0056.2 mwAATCCCCAchy MA0056.3 AATCCCCA |
| Binding Sites: | MA0056.3.17 MA0056.3.13 MA0056.3.11 MA0056.1.1 MA0056.1.10 MA0056.1.11 MA0056.1.12 MA0056.1.13 MA0056.1.14 MA0056.1.15 MA0056.1.16 MA0056.1.17 MA0056.1.18 MA0056.1.19 MA0056.1.2 MA0056.1.20 MA0056.1.3 MA0056.1.4 MA0056.1.5 MA0056.1.6 MA0056.1.7 MA0056.1.8 MA0056.1.9 MA0057.1.1 MA0057.1.10 MA0057.1.11 MA0057.1.12 MA0057.1.13 MA0057.1.14 MA0057.1.15 MA0057.1.16 MA0057.1.2 MA0057.1.3 MA0057.1.4 MA0057.1.5 MA0057.1.6 MA0057.1.7 MA0057.1.8 MA0057.1.9 MA0056.2.1 MA0056.2.10 / MA0056.2.8 MA0056.2.11 / MA0056.2.9 MA0056.2.10 / MA0056.2.12 MA0056.2.12 / MA0056.2.13 MA0056.2.13 / MA0056.2.14 MA0056.2.14 / MA0056.2.15 MA0056.2.15 / MA0056.2.16 MA0056.2.17 MA0056.2.16 / MA0056.2.18 MA0056.2.18 / MA0056.2.19 MA0056.2.2 MA0056.2.20 MA0056.2.3 MA0056.2.4 MA0056.2.3 / MA0056.2.5 MA0056.2.4 / MA0056.2.6 MA0056.2.5 / MA0056.2.7 MA0056.2.6 / MA0056.2.8 MA0056.2.7 / MA0056.2.9 MA0056.2.1 MA0056.2.11 MA0056.2.17 MA0056.2.19 MA0056.2.20 MA0056.3.1 MA0056.3.10 / MA0056.3.3 / MA0056.3.5 / MA0056.3.6 MA0056.3.12 / MA0056.3.19 / MA0056.3.2 MA0056.3.14 / MA0056.3.8 MA0056.3.15 MA0056.3.16 / MA0056.3.4 / MA0056.3.9 MA0056.3.18 MA0056.3.20 MA0056.3.7 |
| Publications: | Morris J. F., Hromas R., Rauscher III F. J. Characterization of the DNA-binding properties of the myeloid zinc finger protein MZF1: two independent DNA-binding domains recognize two DNA consensus sequences with a common G-rich core. Mol. Cell. Biol. 14:1786-1795 (1994). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.