Transcription Factor
| Accessions: | PDX1_DBD (HumanTF 1.0), PDX1 (HT-SELEX2 May2017) |
| Names: | Glucose-sensitive factor, GSF, IDX-1, Insulin promoter factor 1, Insulin upstream factor 1, IPF-1, Islet/duodenum homeobox-1, IUF-1, Pancreas/duodenum homeobox protein 1, PDX-1, PDX1, PDX1_HUMAN, Somatostatin-transactivating factor 1, STF-1, ENSG00000139515 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | P52945 |
| Notes: | Ensembl ID: ENSG00000139515; DNA-binding domain sequence; TF family: homeodomain; Clone source: Synt_2, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 131 |
| Pfam Domains: | 49-105 Homeobox domain |
| Sequence: (in bold interface residues) | 1 PFPEGAEPGVLEEPNRVQLPFPWMKSTKAHAWKGQWAGGAYAAEPEENKRTRTAYTRAQL 60 61 LELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGG 120 121 GVAEPEQDCAV |
| Interface Residues: | 21, 25, 49, 50, 51, 52, 90, 91, 93, 94, 97, 98, 100, 101, 102, 105 |
| 3D-footprint Homologues: | 1au7_A, 3d1n_M, 6a8r_A, 1fjl_B, 5zfz_A, 3cmy_A, 8ejp_B, 1puf_A, 8pmf_A, 3lnq_A, 1nk2_P, 1zq3_P, 2lkx_A, 6m3d_C, 1jgg_B, 2hos_A, 8eml_B, 1puf_B, 9b8u_A, 7q3o_C, 5jlw_D, 2ld5_A, 8ik5_C, 1b72_A, 6es3_K, 4xrs_G, 3a01_E, 1ig7_A, 3rkq_B, 8osb_E, 5flv_I, 2hdd_A, 5zjt_E, 4cyc_A, 2r5y_A, 7psx_B, 5hod_A, 1le8_A, 2xsd_C, 7xrc_C, 1e3o_C, 4qtr_D, 1o4x_A, 1du0_A |
| Binding Motifs: | PDX1_DBD_1 syAATTArsrsyAATTAr PDX1_DBD_2 symATTAr PDX1_3 yTAATkrc PDX1_methyl_1 yTAATkrc PDX1_methyl_2 rTCrTTAr |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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