Transcription Factor
| Accessions: | ASCL1 (HT-SELEX2 May2017) |
| Names: | ASCL1, ENSG00000139352 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 118 |
| Pfam Domains: | 35-84 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 RQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPN 60 61 GAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSNDLNSMA |
| Interface Residues: | 36, 37, 39, 40, 41, 43, 44 |
| 3D-footprint Homologues: | 2ypa_A, 5eyo_A, 2ql2_D, 6od3_F, 2ypa_B, 7z5k_B, 5i50_B |
| Binding Motifs: | ASCL1_2 rrCAGCTGcy ASCL1_methyl_1 rrCAGCTGyy |
| Related annotations: | PaperBLAST |
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