Transcription Factor
| Accessions: | T014207_1.02 (CISBP 1.02), MYCN_HUMAN (HOCOMOCO 10), P04198 (JASPAR 2024) |
| Names: | MYCN, T014207_1.02;, bHLHe37, Class E basic helix-loop-helix protein 37, MYCN_HUMAN, N-myc proto-oncogene protein |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | family:bHLH |
| Length: | 464 |
| Pfam Domains: | 9-372 Myc amino-terminal region 382-434 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPP 60 61 LSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGF 120 121 SAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELA 180 181 HPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPG 240 241 GRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTIT 300 301 VRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLK 360 361 SVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKV 420 421 VILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC |
| Interface Residues: | 385, 386, 387, 389, 390, 393, 394, 398, 419 |
| 3D-footprint Homologues: | 1an4_A, 7ssa_L, 5gnj_I, 6g1l_A, 7xi3_A, 5i50_B, 7d8t_A, 4zpk_A, 7xq5_A, 5nj8_D, 1am9_A, 7rcu_E, 5eyo_A, 5v0l_A, 2ypa_B |
| Binding Motifs: | M3642_1.02 ymcCACGTGymv MYCN_HUMAN.H10MO.B|M01343 cCACGTGs MA0104.4 sgCCACGTGGcs MA0104.5 CCACGTGG |
| Binding Sites: | MA0104.5.15 MA0104.5.12 / MA0104.5.4 / MA0104.5.7 / MA0104.5.9 MA0104.5.1 / MA0104.5.19 / MA0104.5.2 / MA0104.5.20 / MA0104.5.5 / MA0104.5.6 MA0104.4.1 MA0104.4.10 MA0104.4.11 MA0104.4.12 MA0104.4.13 MA0104.4.14 MA0104.4.15 MA0104.4.16 MA0104.4.17 MA0104.4.18 MA0104.4.19 MA0104.4.2 MA0104.4.20 MA0104.4.3 MA0104.4.4 MA0104.4.5 MA0104.4.6 MA0104.4.7 MA0104.4.8 MA0104.4.9 MA0104.5.10 / MA0104.5.11 / MA0104.5.3 / MA0104.5.8 MA0104.5.13 MA0104.5.14 MA0104.5.16 MA0104.5.17 MA0104.5.18 |
| Publications: | Chen X, Xu H, Yuan P, Fang F, Huss M, Vega V.B, Wong E, Orlov Y.L, Zhang W, Jiang J, Loh Y.H, Yeo H.C, Yeo Z.X, Narang V, Govindarajan K.R, Leong B, Shahab A, Ruan Y, Bourque G, Sung W.K, Clarke N.D, Wei C.L, Ng H.H. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133:1106-17 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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