Transcription Factor
| Accessions: | 4lll_A (3D-footprint 20231221), 4lll_B (3D-footprint 20231221), 4lll_C (3D-footprint 20231221), 4lll_J (3D-footprint 20231221), 4lln_B (3D-footprint 20231221) |
| Names: | MarR family HTH-type transcriptional regulator mepR, MarR family regulatory protein, MarR family transcriptional regulator, MepA/mepB repressor and autoregulator, MepR, Multidrug efflux MATE transporter transcriptional repressor MepR, Multidrug efflux transporter transcriptional repressor MepR, Q5Y812_STAAU, Transcriptional regulator SlyA, Transcriptional regulator, MarR family |
| Organisms: | Staphylococcus aureus |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | Q5Y812 |
| Length: | 138 |
| Pfam Domains: | 27-87 MarR family 29-87 MarR family 29-96 Winged helix DNA-binding domain 43-76 Winged helix-turn-helix DNA-binding |
| Sequence: (in bold interface residues) | 1 EFTYSYLFRMISHEMKQKADQKLEQFDITNEQGHTLGYLYAHQQDGLTQNDIAKALQRTG 60 61 PTVSNLLRNLERKKLIYRYVDAQDTRRKNIGLTTSGIKLVEAFTSIFDEMEQTLVSQLSE 120 121 EENEQMKANLTKMLSSLQ |
| Interface Residues: | 50, 59, 60, 61, 62, 64, 65, 68, 69, 86 |
| 3D-footprint Homologues: | 7el3_B, 5k98_B, 3dnv_B, 6fix_D, 7dvv_A, 1u8r_B, 2isz_B, 1ddn_B, 1f5t_A, 4lln_I, 5hlg_E |
| Binding Motifs: | 4lll_AB TTnnnTAgAnnTCTAAnnA 4lll_CD TnntTAnnnnTCTAannAA 4lll_IJ TTnnTTAGAnntCTAA 4lll_J cTAa 4lln_AB TTnnTTAgAnnTcTAAnnAAA |
| Binding Sites: | 4lll_G / 4lll_H / 4lll_K / 4lll_L / 4lln_G / 4lln_H |
| Publications: | Birukou I, Seo S.M, Schindler B.D, Kaatz G.W, Brennan R.G. Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR. Nucleic acids research 42:2774-88 (2014). [Pubmed] |
| Related annotations: | PaperBLAST |
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