Transcription Factor

						

			
Accessions: 5d39_C (3D-footprint 20231221)

			
Names: IL-4 Stat, Signal transducer and activator of transcription 6, STAT6_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P42226
Length: 483
Pfam Domains:    25-122 STAT protein, all-alpha domain
  124-362 STAT protein, DNA binding domain
  373-449 SH2 domain
Sequence: 
(in bold interface residues)		   1 QEELKFKTGLRRLQHRVGEIHLLREALEALAMLLQETTGELEAAKALVLKRIQIWKRQQQ   60
  61 LAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTLV  120
 121 TSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFPAKPPLVRADMVTEKQARELESTGEIIN  180
 181 NTVPLENSIPGNCCSALFKNLLLKKIKRCETESVTEEKCAVLFSASFTLGPGKLPIQLQA  240
 241 LSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGT  300
 301 NRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLT  360
 361 KRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGGSPQIE  420
 421 NIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGVPATIKM  480
 481 TVE
Interface Residues: 135, 249, 250, 251, 252, 253
3D-footprint Homologues: 1bf5_A, 1bg1_A, 4y5w_B
Binding Motifs: 5d39_AC TTCCnGGAA
Binding Sites: 5d39_N
5d39_M
			
Publications: Li J, Rodriguez JP, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S. Structural basis for DNA recognition by STAT6. Proc Natl Acad Sci U S A 113:13015-13020 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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