Transcription Factor

						

			
Accessions: 5mhk_A (3D-footprint 20231221)

			
Names: Alpha-4 protein, ICP4_HHV11, Infected cell protein 4, Major viral transcription factor ICP4, RS1, Transcriptional activator IE175
Organisms: Human herpes simplex virus 1, Human herpesvirus 1 (strain 17) (HHV-1)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P08392
Length: 186
Pfam Domains:    12-184 Herpesvirus ICP4-like protein N-terminal region
Sequence: 
(in bold interface residues)		   1 GAFYARYRDGYVSGEPWPGAGPPPPGRVLYGGLGDSRPGLWGAPEAEEARRRFEASGAPA   60
  61 AVWAPELGDAAQQYALITRLLYTPDAEAMGWLQNPRVVPGDVALDQACFRISGAARNSSS  120
 121 FITGSVARAVPHLGYAMAAGRFGWGLAHAAAAVAMSRRYDRAQKGFLLTSLRRAYAPLLA  180
 181 RENAAL
Interface Residues: 90, 93, 94, 97, 119, 120, 157, 158, 172, 177, 180, 181
3D-footprint Homologues: 1puf_A, 5mhj_A, 1uaa_B
Binding Motifs: 5mhk_A tCGt
5mhk_AB CknATCGy
Binding Sites: 5mhk_E
5mhk_F
			
Publications: Tunnicliffe RB, Lockhart-Cairns MP, Levy C, Mould AP, Jowitt TA, Sito H, Baldock C, Sandri-Goldin RM, Golovanov AP. The herpes viral transcription factor ICP4 forms a novel DNA recognition complex. Nucleic Acids Res 45:8064-8078 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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