Transcription Factor
| Accessions: | UP00598B (UniPROBE 20160601) |
| Names: | DKFZp781N2395, intestine-specific homeobox, ISX_R83Q, MGC138417, Pix-1, RAX-like homeobox, RAXLX |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | intestine-specific homeobox: Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine. |
| Length: | 90 |
| Pfam Domains: | 18-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 LEKPPKDQPQEGRKSKQRVRTTFTTEQLHELEKIFHFTHYPDVHIRSQLAARINLPEARV 60 61 QIWFQNQRAKWRKQEKIGNLGAPQQLSEAS |
| Interface Residues: | 15, 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 72, 73 |
| 3D-footprint Homologues: | 2ld5_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 5zfz_A, 6m3d_C, 1jgg_B, 3lnq_A, 2lkx_A, 3d1n_M, 1nk2_P, 1zq3_P, 7q3o_C, 6es3_K, 1ig7_A, 5flv_I, 3l1p_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 1b72_A, 4cyc_A, 1e3o_C, 1le8_A, 2xsd_C, 1o4x_A, 1du0_A, 4qtr_D, 4xrm_B, 8g87_X |
| Binding Motifs: | UP00598B_1 ykyrscmYTAATTAAkmwsckg UP00598B_2 gkcmscryTAATTArkvhkssb |
| Binding Sites: | ACCAATTA ACTAATTA ATAATTGG ATTAATTA CAATTAAA CAATTAAC CAATTAAG CCAATTAA CCAATTAG CCTAATTA CTAATTAA CTAATTAG CTTAATTA GCAATTAA GCCAATTA GCTAATTA GTAATTAA GTTAATTA TAATTAAA TAATTAGA TAATTGGA TCAATTAA TTAATTAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.