Transcription Factor
| Accessions: | UP00630A (UniPROBE 20160601) |
| Names: | DKFZp686M1631, FLJ23461, MGC10859, MGC16203, MGC5521, Vav-interacting Krueppel-like protein, VIK, VIK-1, zinc finger protein 655, ZNF655_REF |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | zinc finger protein 655: This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Length: | 261 |
| Pfam Domains: | 22-44 C2H2-type zinc finger 22-42 C2H2-type zinc finger 22-44 Zinc finger, C2H2 type 36-60 Zinc-finger double domain 49-70 C2H2-type zinc finger 50-72 Zinc finger, C2H2 type 50-72 C2H2-type zinc finger 64-86 Zinc-finger double domain 102-123 Zinc-finger double domain 113-133 C2H2-type zinc finger 113-135 Zinc finger, C2H2 type 113-135 C2H2-type zinc finger 141-164 C2H2-type zinc finger 183-199 Zinc-finger double domain 189-205 C2H2-type zinc finger 190-212 Zinc finger, C2H2 type 190-212 C2H2-type zinc finger 205-228 Zinc-finger double domain 218-240 Zinc finger, C2H2 type 218-242 C2H2-type zinc finger 218-240 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 ESLMDLSHLNKWESIPNTEKSYKCDVCGKIFHQSSALTRHQRIHTREKPYKCKECEKSFS 60 61 QSSSLSRHKRIHTREKPYKCEASDKSCEASDKSCSPSSGIIQHKKIHTRAKSYKCSSCER 120 121 VFSRSVHLTQHQKIHKEMPCKCTVCGSDFCHTSYLLEHQRVHHEEKAYEYDEYGLAYIKQ 180 181 QGIHFREKPYTCSECGKDFRLNSHLIQHQRIHTGEKAHECNECGKAFSQTSCLIQHHKMH 240 241 RKEKSYECNEYEGSFSHSSDL |
| Interface Residues: | 5, 7, 10, 11, 22, 32, 33, 34, 35, 36, 38, 39, 40, 41, 42, 43, 45, 60, 61, 62, 63, 64, 65, 66, 67, 68, 71, 88, 89, 90, 91, 92, 93, 95, 96, 97, 98, 99, 102, 123, 124, 125, 126, 127, 129, 130, 150, 151, 152, 153, 154, 157, 177, 178, 179, 180, 183, 186, 200, 201, 202, 203, 204, 207, 213, 227, 228, 229, 230, 231, 232, 235, 239, 257, 259, 260 |
| 3D-footprint Homologues: | 2lt7_A, 5yel_A, 7w1m_H, 7ysf_A, 2kmk_A, 1tf3_A, 7y3l_A, 7n5w_A, 6jnm_A, 3uk3_C, 8ssu_A, 2gli_A, 8gn3_A, 1g2f_F, 5kkq_D, 1tf6_A, 6u9q_A, 4x9j_A, 1llm_D, 7txc_E, 5kl3_A, 8ssq_A, 1mey_C, 5und_A, 2drp_D, 1f2i_J, 5k5i_A, 4m9v_C, 8h9h_G, 7eyi_G, 7y3m_I, 2i13_A, 6e94_A, 6wmi_A, 6a57_A, 2jpa_A, 1ubd_C, 6ml4_A, 5v3j_F, 6blw_A, 2wbs_A, 5ei9_F, 8cuc_F, 5yj3_D |
| Binding Motifs: | UP00630A_1 ywmakrtATGCTAAyttwgmmr UP00630A_2 ywhwkrtATGCTAAyywwgmmv |
| Binding Sites: | AATTAGCA ATGCTAAT TATGCTAA TATTAGCA AAATGCTA AAGCTAAC AATGCTAA AATGCTAC AGGCTAAC AGTTAGCA ATGCTAAA ATGCTAAC ATGCTACA ATGCTACC ATGTAGCA ATGTTAGC CATGCTAA CGTTAGCA GATGCTAA GTAGCATA GTATGCTA TAGCATAA TGCTAACA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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