Transcription Factor

						

			
Accessions: NFIX_full (HumanTF 1.0)

			
Names: CCAAT-box-binding transcription factor, CTF, NF-I/X, NF1-X, NFI-X, NFIX, NFIX_HUMAN, Nuclear factor 1 X-type, Nuclear factor 1/X, Nuclear factor I/X, TGGCA-binding protein
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: Q14938
Notes: Ensembl ID: ENSG00000008441; Full protein sequence; TF family: NFI; Clone source: Megaman
Length: 511
Pfam Domains:     17-54 Nuclear factor I protein pre-N-terminus
   77-177 MH1 domain
  221-510 CTF/NF-I family transcription modulation region
Sequence: 
(in bold interface residues)		   1 MEMSWARQSLAGIPAACDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDE   60
  61 ERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDFVLTITGKKPPCCVLSNPDQKG  120
 121 KIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTI  180
 181 KELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQ  240
 241 TPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPSTSTTKRPKSIDDSEMESPVDD  300
 301 VFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLP  360
 361 VLAGVRPGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGS  420
 421 GQATGQPNGSGQGKVPGSFLLPPPPPVARPVPLPMPDSKSTSTAPDGAALTPPSPSFATT  480
 481 GASSANRFVSIGPRDGNFLNIPQQSQSWFL*
Interface Residues: 47, 50, 51, 55, 387, 434
3D-footprint Homologues: 2lkx_A, 6n7w_H
Binding Motifs: NFIX_full yTGGCacggTGCCAA
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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