Transcription Factor

						

			
Accessions: 4s0h_B (3D-footprint 20231221), 4s0h_F (3D-footprint 20231221), 6wc2_N (3D-footprint 20231221)

			
Names: Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Homeobox protein Nkx-2.5, NKX25_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P52952
Length: 53
Pfam Domains:      1-53 Homeobox domain
Sequence: 
(in bold interface residues)		   1 RVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKSK
Interface Residues: 1, 39, 40, 42, 43, 46, 47, 50, 51
3D-footprint Homologues: 2hdd_A, 1nk2_P, 7psx_B, 5hod_A, 3rkq_B, 2r5y_A, 6a8r_A, 1au7_A, 3d1n_M, 2hos_A, 7q3o_C, 1fjl_B, 5jlw_D, 4cyc_A, 2h1k_B, 6es3_K, 1b72_A, 4xrs_G, 2ld5_A, 1puf_A, 1ig7_A, 5zfz_A, 3a01_E, 6m3d_C, 5flv_I, 3lnq_A, 2lkx_A, 1jgg_B, 3cmy_A, 1e3o_C, 2xsd_C, 1le8_A, 7xrc_C, 4j19_B, 2h8r_B, 1zq3_P, 1k61_B, 4xrm_B, 1o4x_A, 3l1p_A, 1mnm_C, 1du0_A, 1puf_B, 8g87_X, 5zjt_E, 4qtr_D
Binding Motifs: 4s0h_AB CacnnnnGAAGnG
4s0h_EF CACnnnnnAAGTG
4s0h_F aAGtG
6wc2_IJN CTAnnnnnnGAAAAnGC
Binding Sites: 4s0h_C / 4s0h_G
4s0h_D / 4s0h_H
6wc2_E
6wc2_F
			
Publications: Pradhan L, Gopal S, Li S, Ashur S, Suryanarayanan S, Kasahara H, Nam HJ. Intermolecular Interactions of Cardiac Transcription Factors NKX2. 5 and TBX5 55:1702-10 (Biochemistry.). [Pubmed]


Lei X, Zhao J, Sagendorf JM, Rajashekar N, Xu J, Dantas Machado AC, Sen C, Rohs R, Feng P, Chen L. Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J Mol Biol 432:5499-5508 (2020). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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