Transcription Factor
| Accessions: | ZNF23 (HT-SELEX2 May2017) |
| Names: | ENSG00000167377, ZNF23 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: KRAB_Znf_C2H2 experiment: HT-SELEX Hamming distance: 2 cycle: 3, TF family: KRAB_Znf_C2H2 experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 4 |
| Length: | 641 |
| Pfam Domains: | 183-204 Zinc-finger double domain 194-217 C2H2-type zinc finger 194-216 C2H2-type zinc finger 194-216 Zinc finger, C2H2 type 211-233 Zinc-finger double domain 222-242 C2H2-type zinc finger 222-244 C2H2-type zinc finger 222-244 Zinc finger, C2H2 type 239-260 Zinc-finger double domain 250-272 Zinc finger, C2H2 type 250-272 C2H2-type zinc finger 264-289 Zinc-finger double domain 278-300 C2H2-type zinc finger 278-300 C2H2-type zinc finger 295-315 Zinc-finger double domain 305-326 C2H2-type zinc finger 306-328 C2H2-type zinc finger 306-328 Zinc finger, C2H2 type 323-344 Zinc-finger double domain 333-353 C2H2-type zinc finger 334-356 C2H2-type zinc finger 334-356 Zinc finger, C2H2 type 349-373 Zinc-finger double domain 362-384 C2H2-type zinc finger 362-384 Zinc finger, C2H2 type 362-382 C2H2-type zinc finger 379-400 Zinc-finger double domain 389-400 C2H2-type zinc finger 390-412 C2H2-type zinc finger 390-412 Zinc finger, C2H2 type 407-428 Zinc-finger double domain 417-438 C2H2-type zinc finger 418-440 C2H2-type zinc finger 418-440 Zinc finger, C2H2 type 433-456 Zinc-finger double domain 445-456 C2H2-type zinc finger 446-468 C2H2-type zinc finger 446-468 Zinc finger, C2H2 type 461-485 Zinc-finger double domain 474-496 Zinc finger, C2H2 type 488-512 Zinc-finger double domain 502-524 Zinc finger, C2H2 type 502-512 C2H2-type zinc finger 502-524 C2H2-type zinc finger 517-541 Zinc-finger double domain 530-550 C2H2-type zinc finger 547-567 Zinc-finger double domain 558-580 Zinc finger, C2H2 type 558-580 C2H2-type zinc finger 558-580 C2H2-type zinc finger 572-596 Zinc-finger double domain 586-608 Zinc finger, C2H2 type 604-623 Zinc-finger double domain 614-636 C2H2-type zinc finger 614-636 Zinc finger, C2H2 type 616-632 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 ENYGNVASLGFPLLKPAVISQLEGGSELGGSSPLAAGTGLQGLQTDIQTDNDLTKEMYEG 60 61 KENVSFELQRDFSQETDFSEASLLEKQQEVHSAGNIKKEKSNTIDGTVKDETSPVEECFF 120 121 SQSSNSYQCHTITGEQPSGCTGLGKSISFDTKLVKHEIINSEERPFKCEELVEPFRCDSQ 180 181 LIQHQENNTEEKPYQCSECGKAFSINEKLIWHQRLHSGEKPFKCVECGKSFSYSSHYITH 240 241 QTIHSGEKPYQCKMCGKAFSVNGSLSRHQRIHTGEKPYQCKECGNGFSCSSAYITHQRVH 300 301 TGEKPYECNDCGKAFNVNAKLIQHQRIHTGEKPYECNECGKGFRCSSQLRQHQSIHTGEK 360 361 PYQCKECGKGFNNNTKLIQHQRIHTGEKPYECTECGKAFSVKGKLIQHQRIHTGEKPYEC 420 421 NECGKAFRCNSQFRQHLRIHTGEKPYECNECGKAFSVNGKLMRHQRIHTGEKPFECNECG 480 481 RCFTSKRNLLDHHRIHTGEKPYQCKECGKAFSINAKLTRHQRIHTGEKPFKCMECEKAFS 540 541 CSSNYIVHQRIHTGEKPFQCKECGKAFHVNAHLIRHQRSHTGEKPFRCVECGKGFSFSSD 600 601 YIIHQTVHTWKKPYMCSVCGKAFRFSFQLSQHQSVHSEGKS |
| Interface Residues: | 177, 179, 205, 208, 222, 233, 234, 235, 236, 238, 239, 241, 242, 245, 260, 261, 262, 263, 264, 266, 267, 289, 290, 291, 292, 295, 317, 318, 319, 320, 323, 327, 344, 345, 347, 348, 350, 351, 372, 373, 374, 375, 376, 378, 379, 382, 383, 401, 402, 403, 404, 407, 408, 428, 429, 430, 431, 432, 433, 434, 435, 436, 456, 457, 458, 459, 460, 462, 463, 484, 485, 486, 487, 488, 490, 491, 494, 513, 514, 515, 516, 519, 525, 539, 541, 542, 543, 544, 547, 551, 568, 569, 571, 572, 575, 596, 597, 599, 600, 603 |
| 3D-footprint Homologues: | 2gli_A, 2kmk_A, 1llm_D, 6blw_A, 2jpa_A, 4x9j_A, 5kl3_A, 1f2i_J, 5ei9_F, 8ssu_A, 1tf6_A, 7w1m_H, 7ysf_A, 5yel_A, 2lt7_A, 6jnm_A, 7y3l_A, 2i13_A, 5kkq_D, 6u9q_A, 2drp_D, 8ssq_A, 7eyi_G, 6a57_A, 5und_A, 1g2f_F, 5v3j_F, 4m9v_C, 3uk3_C, 1tf3_A, 6ml4_A, 8gn3_A, 6wmi_A, 5k5i_A, 6e94_A, 1ubd_C, 8cuc_F, 7n5w_A, 7txc_E, 5yj3_D, 8h9h_G, 7y3m_I, 2wbs_A, 1mey_C, 5k5l_F |
| Binding Motifs: | ZNF23_2 kkGkCGCGGCCATGGGyGh ZNF23_methyl_1 bggkcGCGGCCATGGGtGw |
| Related annotations: | PaperBLAST |
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