Transcription Factor

						

			
Accessions: Zfp740_DBD (HumanTF 1.0), UP00022A (UniPROBE 20160601)

			
Names: D3Z6P2_MOUSE, Fragment, Protein Zfp740, Zfp740, Zinc finger protein 740, Znf740
Organisms: Mus musculus
Libraries: HumanTF 1.0 1, UniPROBE 20160601 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: Q6NZQ6
Description: Zinc finger protein 740
Notes: Ensembl ID: ENSMUSG00000046897; DNA-binding domain sequence; TF family: znfC2H2; Clone source: Hughes lab.
Length: 108
Pfam Domains:     16-38 Zinc finger, C2H2 type
    16-38 C2H2-type zinc finger
    30-53 Zinc-finger double domain
    44-66 Zinc finger, C2H2 type
    44-66 C2H2-type zinc finger
    58-82 Zinc-finger double domain
    72-93 C2H2-type zinc finger
    72-94 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 VVEQNGSFQVKIPKNFICEHCFGAFRSSYHLKRHVLIHTGEKPFECDVCDMRFIQKYHLE   60
  61 RHKRVHSGEKPYQCERCHQCFSRTDRLLRHKRMCQGCQSKTSEGQFSL
Interface Residues: 16, 26, 27, 28, 29, 30, 32, 33, 54, 55, 56, 57, 58, 60, 61, 62, 83, 84, 85, 86, 87, 88, 89, 90
3D-footprint Homologues: 2kmk_A, 3uk3_C, 1tf3_A, 6jnm_A, 8cuc_F, 7y3l_A, 5v3j_F, 7n5w_A, 5ei9_F, 2jpa_A, 1mey_C, 5kl3_A, 7ysf_A, 6wmi_A, 5k5i_A, 8ssq_A, 7w1m_H, 5und_A, 2gli_A, 1g2f_F, 5k5l_F, 8ssu_A, 1tf6_A, 6ml4_A, 4x9j_A, 8gn3_A, 2i13_A, 6blw_A, 5kkq_D, 1ubd_C, 6u9q_A, 8h9h_G, 7eyi_G, 6e94_A, 2lt7_A, 7y3m_I, 6a57_A, 7txc_E, 2drp_D, 1f2i_J, 5yj3_D, 1llm_D, 2wbs_A, 5yel_A, 4m9v_C
Binding Motifs: UP00022A_1 ycyccCCCCCCmmwys
Zfp740_DBD mCCCCCCCac
UP00022A_2 rrrtwCCCCCCggrrry
Binding Sites: AAGGGGGG
ACACCCCC
ACCCCCCA
ACCCCCCC
AGGGGGGG
ATGGGGGG
CACCCCCA
CACCCCCC
CCCCCCAA
CCCCCCAC
CCCCCCAG
CCCCCCCA
CCCCCCCC
CCCCCCCG
CCCCCCTC
GACCCCCC
GCACCCCC
GCCCCCCC
GGGGGGGA
TCCCCCCA
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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