Transcription Factor
| Accessions: | E2F4_DBD (HumanTF 1.0), E2F4 (HT-SELEX2 May2017) |
| Names: | E2F-4, E2F4, E2F4_HUMAN, Transcription factor E2F4, ENSG00000205250 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q16254 |
| Notes: | Ensembl ID: ENSG00000205250; DNA-binding domain sequence; TF family: E2F; Clone source: Gene synthesis, TF family: E2F experiment: HT-SELEX Hamming distance: 2 cycle: 3 |
| Length: | 104 |
| Pfam Domains: | 15-81 E2F/DP family winged-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 EAGPQAPPPPGTPSRHEKSLGLLTTKFVSLLQEAKDGVLDLKLAADTLAVRQKRRIYDIT 60 61 NVLEGIGLIEKKSKNSIQWKGVGPGCNTREIADKLIELKAEIEE |
| Interface Residues: | 15, 52, 53, 54, 55, 57, 78 |
| 3D-footprint Homologues: | 4yo2_A, 1cf7_A, 2qby_A, 1cf7_B |
| Binding Motifs: | E2F4_DBD_1 AATGGCGCCAAA E2F4_DBD_2 TTTGGCGCCAAA E2F4_1 wTtTGGCGCCawww |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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