Transcription Factor

						

			
Accessions: Q6P9A1 (JASPAR 2024)

			
Names: ZN530_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q6P9A1
Length: 599
Pfam Domains:     14-54 KRAB box
  234-249 Zinc-finger double domain
  238-261 C2H2-type zinc finger
  239-261 C2H2-type zinc finger
  239-261 Zinc finger, C2H2 type
  254-278 Zinc-finger double domain
  266-289 C2H2-type zinc finger
  267-289 C2H2-type zinc finger
  267-289 Zinc finger, C2H2 type
  281-305 Zinc-finger double domain
  295-317 Zinc finger, C2H2 type
  295-317 C2H2-type zinc finger
  295-317 C2H2-type zinc finger
  311-334 Zinc-finger double domain
  322-345 C2H2-type zinc finger
  323-345 Zinc finger, C2H2 type
  323-345 C2H2-type zinc finger
  337-362 Zinc-finger double domain
  350-369 C2H2-type zinc finger
  351-373 Zinc finger, C2H2 type
  351-373 C2H2-type zinc finger
  365-390 Zinc-finger double domain
  378-401 C2H2-type zinc finger
  397-417 Zinc-finger double domain
  407-429 C2H2-type zinc finger
  407-429 Zinc finger, C2H2 type
  407-429 C2H2-type zinc finger
  423-445 Zinc-finger double domain
  434-457 C2H2-type zinc finger
  435-457 Zinc finger, C2H2 type
  435-457 C2H2-type zinc finger
  450-474 Zinc-finger double domain
  462-485 C2H2-type zinc finger
  463-485 Zinc finger, C2H2 type
  463-485 C2H2-type zinc finger
  478-500 Zinc-finger double domain
  490-500 C2H2-type zinc finger
  491-513 C2H2-type zinc finger
  491-513 Zinc finger, C2H2 type
  505-529 Zinc-finger double domain
  518-541 C2H2-type zinc finger
  519-541 C2H2-type zinc finger
  519-541 Zinc finger, C2H2 type
  533-558 Zinc-finger double domain
  546-569 C2H2-type zinc finger
  547-569 Zinc finger, C2H2 type
  547-569 C2H2-type zinc finger
  562-585 Zinc-finger double domain
  574-597 C2H2-type zinc finger
  575-597 Zinc finger, C2H2 type
  575-597 C2H2-type zinc finger
Sequence: 
(in bold interface residues)		   1 MAAALRAPTQQVFVAFEDVAIYFSQEEWELLDEMQRLLYRDVMLENFAVMASLGCWCGAV   60
  61 DEGTPSAESVSVEELSQGRTPKADTSTDKSHPCEICTPVLRDILQMIELHASPCGQKLYL  120
 121 GGASRDFWMSSNLHQLQKLDNGEKLFKVDGDQASFMMNCRFHVSGKPFTFGEVGRDFSAT  180
 181 SGLLQHQVTPTIERPHSRIRHLRVPTGRKPLKYTESRKSFREKSVFIQHQRADSGERPYK  240
 241 CSECGKSFSQSSGFLRHRKAHGRTRTHECSECGKSFSRKTHLTQHQRVHTGERPYDCSEC  300
 301 GKSFRQVSVLIQHQRVHTGERPYECSECGKSFSHSTNLYRHRSAHTSTRPYECSECGKSF  360
 361 SHSTNLFRHWRVHTGVRPYECSECGKAFSCNIYLIHHQRFHTGERPYVCSECGKSFGQKS  420
 421 VLIQHQRVHTGERPYECSECGKVFSQSSGLFRHRRAHTKTKPYECSECEKSFSCKTDLIR  480
 481 HQTVHTGERPYECSVCGKSFIRKTHLIRHQTVHTNERPYECDECGKSYSQSSALLQHRRV  540
 541 HTGERPYECRECGKSFTRKNHLIQHKTVHTGERPYECSECGKSFSQSSGLLRHRRVHVQ
Interface Residues: 250, 251, 252, 253, 255, 256, 277, 278, 280, 281, 284, 305, 306, 308, 309, 312, 334, 335, 336, 337, 339, 340, 362, 363, 364, 365, 368, 372, 389, 390, 392, 393, 396, 417, 418, 420, 421, 423, 424, 446, 447, 448, 449, 450, 452, 454, 474, 475, 476, 477, 479, 480, 484, 486, 500, 501, 502, 504, 505, 507, 508, 510, 511, 512, 514, 519, 529, 530, 531, 532, 533, 535, 536, 537, 557, 558, 559, 560, 561, 562, 563, 564, 565, 585, 586, 587, 588, 589, 591, 592
3D-footprint Homologues: 2drp_D, 1ubd_C, 6jnm_A, 7w1m_H, 5k5l_F, 5yj3_D, 5v3j_F, 5ei9_F, 8ssq_A, 8ssu_A, 3uk3_C, 2gli_A, 5k5i_A, 6u9q_A, 1tf6_A, 6e94_A, 5yel_A, 6ml4_A, 5kkq_D, 8gn3_A, 7ysf_A, 6blw_A, 2lt7_A, 2jpa_A, 2kmk_A, 7n5w_A, 1tf3_A, 8cuc_F, 7y3l_A, 1g2f_F, 5kl3_A, 7txc_E, 4x9j_A, 1f2i_J, 2wbs_A, 8h9h_G, 4m9v_C, 7y3m_I, 6a57_A, 1llm_D
Binding Motifs: MA1981.1 GmArGGmrAGGGsCrgsv
MA1981.2 GmArGGmrAGGGsC
			
Publications: Shaw G, Morse S, Ararat M, Graham FL. Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells. FASEB J 16:869-71 (2002). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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