Transcription Factor

						

			
Accessions: 5flv_I (3D-footprint 20231221)

			
Names: HOMEOBOX PROTEIN NKX-2.5, T-BOX TRANSCRIPTION FACTOR TBX5, T-box protein 5, TBX5_MOUSE
Organisms: Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 226
Pfam Domains:      1-55 Homeobox domain
   58-226 T-box
Sequence: 
(in bold interface residues)		   1 PRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKSKRQRVFL   60
  61 HERELWLKFHEVGTEMIITKAGRRMFPSYKVVTGLNPKTKYILLMDIVPADDHRYKFADN  120
 121 KWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKY  180
 181 QPRLHIVKADSTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFR
Interface Residues: 2, 40, 41, 43, 44, 47, 48, 51, 52, 55, 83, 204, 205, 221, 224, 225
3D-footprint Homologues: 6es3_K, 4xrs_G, 2ld5_A, 1puf_A, 7q3o_C, 1ig7_A, 5zfz_A, 4cyc_A, 2h1k_B, 5flv_I, 3lnq_A, 2lkx_A, 1jgg_B, 1au7_A, 3a01_E, 2hdd_A, 1nk2_P, 6m3d_C, 1fjl_B, 5hod_A, 3rkq_B, 2r5y_A, 6a8r_A, 1b72_A, 3cmy_A, 2hos_A, 7psx_B, 5jlw_D, 1le8_A, 2xsd_C, 1e3o_C, 7xrc_C, 4j19_B, 1zq3_P, 1du0_A, 3l1p_A, 1mnm_C, 1puf_B, 5zjt_E, 8g87_X, 1k61_B, 4qtr_D, 1o4x_A, 2x6v_A, 6f59_B, 1xbr_B, 1h6f_B, 4a04_B
Binding Motifs: 5flv_I CACnnTTGAAGnGg
Binding Sites: 5flv_J
5flv_K
			
Publications: Luna-Zurita L, Stirnimann CU, Glatt S, Kaynak BL, Thomas S, Baudin F, Samee MA, He D, Small EM, Mileikovsky M, Nagy A, Holloway AK, Pollard KS, Müller CW, Bruneau BG. Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis. Cell 164:999-1014 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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