Transcription Factor

Accessions: ZN384_HUMAN (HOCOMOCO 10), Q8TF68 (JASPAR 2024)
Names: CAG repeat protein 1, CAS-interacting zinc finger protein, Nuclear matrix protein 4, Nuclear matrix transcription factor 4, Trinucleotide repeat-containing gene 1 protein, Zinc finger protein 384, ZN384_HUMAN
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q8TF68
Length: 577
Pfam Domains: 244-267 Zinc-finger double domain
255-271 C2H2-type zinc finger
256-278 C2H2-type zinc finger
256-278 Zinc finger, C2H2 type
271-294 Zinc-finger double domain
284-304 C2H2-type zinc finger
284-303 C2H2-type zinc finger
284-306 Zinc finger, C2H2 type
304-328 Zinc-finger double domain
316-331 C2H2-type zinc finger
317-339 C2H2-type zinc finger
317-339 Zinc finger, C2H2 type
332-355 Zinc-finger double domain
345-365 C2H2-type zinc finger
345-364 C2H2-type zinc finger
345-367 Zinc finger, C2H2 type
359-386 Zinc-finger double domain
373-397 Zinc finger, C2H2 type
373-398 C2H2-type zinc finger
380-398 C2H2-type zinc finger
389-413 Zinc-finger double domain
403-425 Zinc finger, C2H2 type
417-444 Zinc-finger double domain
432-456 C2H2-type zinc finger
433-455 Zinc finger, C2H2 type
433-456 C2H2-type zinc finger
Sequence:
(in bold interface residues)
1 MEESHFNSNPYFWPSIPTVSGQIENTMFINKMKDQLLPEKGCGLAPPHYPTLLTVPASVS 60
61 LPSGISMDTESKSDQLTPHSQASVTQNITVVPVPSTGLMTAGVSCSQRWRREGSQSRGPG 120
121 LVITSPSGSLVTTASSAQTFPISAPMIVSALPPGSQALQVVPDLSKKVASTLTEEGGGGG 180
181 GGGGSVAPKPPRGRKKKRMLESGLPEMNDPYVLSPEDDDDHQKDGKTYRCRMCSLTFYSK 240
241 SEMQIHSKSHTETKPHKCPHCSKTFANSSYLAQHIRIHSGAKPYSCNFCEKSFRQLSHLQ 300
301 QHTRIHSKMHTETIKPHKCPHCSKTFANTSYLAQHLRIHSGAKPYNCSYCQKAFRQLSHL 360
361 QQHTRIHTGDRPYKCAHPGCEKAFTQLSNLQSHRRQHNKDKPFKCHNCHRAYTDAASLEV 420
421 HLSTHTVKHAKVYTCTICSRAYTSETYLMKHMRKHNPPDLQQQVQAAAAAAAVAQAQAQA 480
481 QAQAQAQAQAQAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGAAPQGGGGGDSNPNP 540
541 PPQCSFDLTPYKTAEHHKDICLTVTTSTIQVEHLASS
Interface Residues: 239, 241, 242, 245, 266, 267, 268, 269, 270, 273, 274, 294, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304, 307, 317, 327, 328, 329, 330, 331, 333, 334, 337, 338, 355, 356, 357, 358, 359, 361, 362, 366, 385, 386, 387, 388, 389, 390, 391, 392, 413, 414, 415, 416, 417, 419, 420, 424, 443, 444, 445, 446, 447, 449, 450, 453, 487, 500, 502, 504, 505, 508, 512
3D-footprint Homologues: 8ssq_A, 5und_A, 8ssu_A, 5yel_A, 3uk3_C, 5v3j_F, 4x9j_A, 2i13_A, 8gn3_A, 1llm_D, 1f2i_J, 5k5i_A, 7w1m_H, 1tf6_A, 4m9v_C, 6e94_A, 6a57_A, 7txc_E, 5yj3_D, 6ml4_A, 7ysf_A, 2jpa_A, 1ubd_C, 7n5w_A, 6jnm_A, 5kkq_D, 5ei9_F, 1mey_C, 5kl3_A, 6wmi_A, 2kmk_A, 5k5l_F, 8h9h_G, 7eyi_G, 7y3m_I, 2lt7_A, 1tf3_A, 6blw_A, 8cuc_F, 7y3l_A, 2wbs_A, 6u9q_A, 2gli_A, 1g2f_F, 2drp_D
Binding Motifs: ZN384_HUMAN.H10MO.C|M01629 gsAAAAAvycks
MA1125.1 wwwmAAAAAAaa
MA1125.2 AAAAAAaa
Binding Sites: MA1125.2.17 / MA1125.2.20
MA1125.2.7
MA1125.2.15
MA1125.2.1 / MA1125.2.10 / MA1125.2.11 / MA1125.2.12 / MA1125.2.14 / MA1125.2.16 / MA1125.2.19 / MA1125.2.2 / MA1125.2.3 / MA1125.2.4
MA1125.1.1
MA1125.1.10
MA1125.1.11
MA1125.1.12
MA1125.1.13
MA1125.1.14
MA1125.1.15
MA1125.1.16
MA1125.1.17
MA1125.1.18
MA1125.1.19
MA1125.1.2
MA1125.1.20
MA1125.1.3
MA1125.1.4
MA1125.1.5
MA1125.1.6
MA1125.1.7
MA1125.1.8
MA1125.1.9
MA1125.2.13
MA1125.2.18
MA1125.2.5 / MA1125.2.8 / MA1125.2.9
MA1125.2.6
Publications: Thunyakitpisal P., Alvarez M., Tokunaga K., Onyia J. E., Hock J., Ohashi N., Feister H., Rhodes S. J., Bidwell J. P. Cloning and functional analysis of a family of nuclear matrix transcription factors (NP/NMP4) that regulate type I collagen expression in osteoblasts.. J. Bone Miner. Res. 16:10-23 (2001). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.