Transcription Factor
| Accessions: | LEF1_MOUSE (HOCOMOCO 10), P27782 (JASPAR 2024) |
| Names: | LEF-1, LEF1_MOUSE, Lymphoid enhancer-binding factor 1 |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 397 |
| Pfam Domains: | 1-211 N-terminal CTNNB1 binding 292-355 Domain of unknown function (DUF1898) 297-364 HMG (high mobility group) box |
| Sequence: (in bold interface residues) | 1 MPQLSGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNESE 60 61 IIPASNGHEVVRQAPSSQEPYHDKAREHPDEGKHPDGGLYNKGPSYSSYSGYIMMPNMNS 120 121 DPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNSKQ 180 181 GMSRHPPAPEIPTFYPLSPGGVGQITPPIGWQGQPVYPITGGFRQPYPSSLSGDTSMSRF 240 241 SHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKP 300 301 LNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQL 360 361 YPGWSARDNYGKKKKRKREKLQESTSGTGPRMTAAYI |
| Interface Residues: | 299, 302, 304, 305, 308, 312, 323, 324, 325, 328, 366, 368, 370, 373, 375, 376, 377, 380 |
| 3D-footprint Homologues: | 2lef_A, 4y60_C, 1j5n_A, 3f27_D, 6jrp_D, 1o4x_B, 3u2b_C, 7m5w_A, 2gzk_A, 4s2q_D, 1hry_A |
| Binding Motifs: | PB0040.1 rrwycCTTTGATstwwm PB0144.1 swrsATCAATCrctww LEF1_MOUSE.H10MO.C|M01191 CTTTGww MA0768.2 wtkCCTTTGATsty MA0768.3 CCTTTGAT |
| Binding Sites: | MA0768.3.19 MA0768.3.1 / MA0768.3.15 / MA0768.3.8 MA0768.2.1 MA0768.2.10 / MA0768.2.12 MA0768.2.11 / MA0768.2.14 MA0768.2.12 / MA0768.2.15 MA0768.2.13 / MA0768.2.16 MA0768.2.14 / MA0768.2.17 MA0768.2.15 / MA0768.2.18 MA0768.2.16 / MA0768.2.19 MA0768.2.17 MA0768.2.18 MA0768.2.19 MA0768.2.2 / MA0768.2.3 MA0768.2.20 MA0768.2.3 / MA0768.2.4 MA0768.2.4 / MA0768.2.5 MA0768.2.5 / MA0768.2.6 MA0768.2.6 / MA0768.2.7 MA0768.2.7 / MA0768.2.9 MA0768.2.10 / MA0768.2.8 MA0768.2.11 / MA0768.2.9 MA0768.2.13 MA0768.2.2 MA0768.2.20 MA0768.2.8 MA0768.3.10 MA0768.3.11 / MA0768.3.12 MA0768.3.13 MA0768.3.14 MA0768.3.16 MA0768.3.17 / MA0768.3.18 MA0768.3.2 MA0768.3.20 MA0768.3.3 / MA0768.3.7 MA0768.3.4 MA0768.3.5 MA0768.3.6 MA0768.3.9 |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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