Transcription Factor
| Accessions: | OTX2 (HT-SELEX2 May2017) |
| Names: | ENSG00000165588, OTX2 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 297 |
| Pfam Domains: | 47-103 Homeobox domain 161-243 Otx1 transcription factor |
| Sequence: (in bold interface residues) | 1 MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPGPWASCPAATPRKQRRERTTFTRAQLDV 60 61 LEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAK 120 121 KKTSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLSDPLSTSSSCMQ 180 181 RSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLN 240 241 QSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL |
| Interface Residues: | 42, 44, 46, 47, 48, 49, 50, 88, 89, 91, 92, 95, 96, 99, 100, 103 |
| 3D-footprint Homologues: | 6m3d_C, 4j19_B, 5zfz_A, 1fjl_B, 1ig7_A, 6a8r_A, 3cmy_A, 2h1k_B, 1puf_A, 3d1n_M, 1nk2_P, 1zq3_P, 3lnq_A, 1jgg_B, 2lkx_A, 7q3o_C, 2ld5_A, 6es3_K, 1au7_A, 4cyc_A, 2r5y_A, 1puf_B, 5flv_I, 3l1p_A, 2hos_A, 1b72_A, 5zjt_E, 3a01_E, 5hod_A, 7psx_B, 5jlw_D, 3rkq_B, 4xrs_G, 2hdd_A, 1le8_A, 1e3o_C, 8g87_X, 6wig_A, 1o4x_A, 1du0_A, 4qtr_D |
| Binding Motifs: | OTX2_2 mTAATCCs OTX2_methyl_1 cTAATCCc |
| Related annotations: | PaperBLAST |
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