Transcription Factor
| Accessions: | UP00603A (UniPROBE 20160601) |
| Names: | CRS2, FPP, Homeobox protein Hox-8, homeobox protein MSX-2, HOX8, MSH, MSX2_REF, PFM, PFM1 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox protein MSX-2: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. |
| Length: | 85 |
| Pfam Domains: | 14-70 Homeobox domain |
| Sequence: (in bold interface residues) | 1 SPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIW 60 61 FQNRRAKAKRLQEAELEKLKMAAKP |
| Interface Residues: | 14, 15, 16, 17, 55, 56, 58, 59, 62, 63, 66, 67, 70 |
| 3D-footprint Homologues: | 5zfz_A, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 1zq3_P, 6m3d_C, 3lnq_A, 2lkx_A, 1nk2_P, 2ld5_A, 7q3o_C, 6es3_K, 1b72_A, 4cyc_A, 5flv_I, 5zjt_E, 4j19_B, 3a01_E, 1jgg_B, 7psx_B, 5hod_A, 2hdd_A, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 2xsd_C, 1e3o_C, 1le8_A, 7xrc_C, 3l1p_A, 1o4x_A, 8g87_X, 1du0_A, 4qtr_D, 1puf_B |
| Binding Motifs: | UP00603A_1 mtwyaaaAAcCAATTAacwmray UP00603A_2 bwyraaaacYAATTAaywhwmby |
| Binding Sites: | GGTAATTA AATTAATT ACCAATTA ACTAATTA AGCAATTA AGTAATTA ATAATTAG ATAATTGG ATCAATTA ATTAATTA ATTAATTG CAATTAAA CAATTATC CCAATTAA CCAATTAG CCTAATTA CTAATTAA CTAATTAG CTTAATTA GATAATTA GCAATTAA GCTAATTA GTAATTAA GTAATTAC TAATTAAA TAATTGCA TAATTGGA TTAATTAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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