Transcription Factor
| Accessions: | Q0VGE8 (JASPAR 2024) |
| Names: | ZN816_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q0VGE8 |
| Length: | 651 |
| Pfam Domains: | 24-62 KRAB box 228-251 C2H2-type zinc finger 229-251 Zinc finger, C2H2 type 244-267 Zinc-finger double domain 257-267 C2H2-type zinc finger 274-296 Zinc-finger double domain 284-307 C2H2-type zinc finger 285-307 C2H2-type zinc finger 285-307 Zinc finger, C2H2 type 299-323 Zinc-finger double domain 312-335 C2H2-type zinc finger 313-335 C2H2-type zinc finger 313-335 Zinc finger, C2H2 type 327-351 Zinc-finger double domain 340-360 C2H2-type zinc finger 341-363 C2H2-type zinc finger 341-363 Zinc finger, C2H2 type 355-379 Zinc-finger double domain 368-384 C2H2-type zinc finger 369-389 C2H2-type zinc finger 369-391 Zinc finger, C2H2 type 383-406 Zinc-finger double domain 397-419 Zinc finger, C2H2 type 411-435 Zinc-finger double domain 425-447 Zinc finger, C2H2 type 425-445 Zinc-finger of C2H2 type 425-436 C2H2-type zinc finger 425-447 C2H2-type zinc finger 440-464 Zinc-finger double domain 452-468 C2H2-type zinc finger 453-471 C2H2-type zinc finger 453-475 Zinc finger, C2H2 type 467-492 Zinc-finger double domain 480-501 C2H2-type zinc finger 481-501 C2H2-type zinc finger 481-503 Zinc finger, C2H2 type 495-520 Zinc-finger double domain 508-529 C2H2-type zinc finger 509-531 C2H2-type zinc finger 509-529 Zinc-finger of C2H2 type 509-531 Zinc finger, C2H2 type 523-547 Zinc-finger double domain 536-548 C2H2-type zinc finger 537-559 C2H2-type zinc finger 537-559 Zinc finger, C2H2 type 552-575 Zinc-finger double domain 565-587 C2H2-type zinc finger 565-587 Zinc finger, C2H2 type 580-603 Zinc-finger double domain 592-607 C2H2-type zinc finger 593-615 C2H2-type zinc finger 593-615 Zinc finger, C2H2 type 607-631 Zinc-finger double domain 620-646 C2H2-type zinc finger 621-643 Zinc finger, C2H2 type 621-643 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MLREEATKKSKEKEPGMALPQGRLTFRDVAIEFSLEEWKCLNPAQRALYRAVMLENYRNL 60 61 EFVDSSLKSMMEFSSTRHSITGEVIHTGTLQRHKSHHIGDFCFPEMKKDIHHFEFQWQEV 120 121 ERNGHEAPMTKIKKLTGSTDRSDHRHAGNKPIKDQLGLSFHSHLPELHMFQTKGKISNQL 180 181 DKSIGASSASESQRISCRLKTHISNKYGKNFLHSSFTQIQEICMREKPCQSNECGKAFNY 240 241 SSLLRRHHITHSREREYKCDVCGKIFNQKQYIVYHHRCHTGEKTYKCNECGKTFTQMSSL 300 301 VCHRRLHTGEKPYKCNECGKTFSEKSSLRCHRRLHTGEKPYKCNECGKTFGRNSALVIHK 360 361 AIHTGEKPYKCNECGKTFSQKSSLQCHHILHTGEKPYKCEECDNVYIRRSHLERHRKIHT 420 421 GEGSYKCKVCDKVFRSDSYLAEHQRVHTGEKPYKCNKCGRSFSRKSSLQYHHTLHTGEKP 480 481 YTCNECGKVFSRRENLARHHRLHAGEKPYKCEECDKVFSRRSHLERHRRIHTGEKPYKCK 540 541 VCDKAFRSDSCLANHTRVHTGEKPYKCNKCAKVFNQKGILAQHQRVHTGEKPYKCNECGK 600 601 VFNQKASLAKHQRVHTAEKPYKCNECGKAFTGQSTLIHHQAIHGCRETLQM |
| Interface Residues: | 295, 298, 302, 324, 326, 327, 330, 351, 352, 353, 354, 355, 380, 381, 382, 383, 386, 389, 407, 408, 410, 411, 413, 414, 416, 417, 420, 435, 436, 437, 438, 439, 442, 445, 463, 464, 465, 466, 467, 470, 492, 493, 494, 495, 498, 501, 519, 520, 521, 522, 523, 526, 529, 532, 537, 546, 548, 549, 550, 551, 553, 554, 558, 575, 576, 577, 578, 579, 582, 603, 604, 605, 606, 607, 610 |
| 3D-footprint Homologues: | 7y3l_A, 7w1m_H, 5v3j_F, 8ssq_A, 8ssu_A, 1tf6_A, 2lt7_A, 2jpa_A, 7n5w_A, 2drp_D, 8h9h_G, 7y3m_I, 1ubd_C, 8cuc_F, 1tf3_A, 2gli_A, 6e94_A, 6u9q_A, 8gn3_A, 7ysf_A, 2kmk_A, 7txc_E |
| Binding Motifs: | MA1719.1 / UN0236.1 rrrkGGGGACATGcwgGg MA1719.2 kGGGGACATGcwgGg |
| Binding Sites: | MA1719.1.1 / UN0236.1.1 MA1719.1.5 / MA1719.1.9 / UN0236.1.10 / UN0236.1.6 MA1719.1.10 / UN0236.1.11 MA1719.1.11 / UN0236.1.12 MA1719.1.12 / UN0236.1.13 MA1719.1.14 / UN0236.1.14 MA1719.1.15 / UN0236.1.15 UN0236.1.16 MA1719.1.16 / UN0236.1.17 MA1719.1.17 / UN0236.1.18 MA1719.1.18 / UN0236.1.19 UN0236.1.2 MA1719.1.19 / UN0236.1.20 MA1719.1.2 / UN0236.1.3 MA1719.1.3 / UN0236.1.4 MA1719.1.4 / UN0236.1.5 MA1719.1.6 / UN0236.1.7 MA1719.1.7 / UN0236.1.8 MA1719.1.8 / UN0236.1.9 MA1719.1.13 MA1719.1.20 MA1719.2.1 / MA1719.2.2 / MA1719.2.3 MA1719.2.10 MA1719.2.11 MA1719.2.12 MA1719.2.13 / MA1719.2.9 MA1719.2.14 / MA1719.2.15 / MA1719.2.16 / MA1719.2.17 / MA1719.2.18 / MA1719.2.19 / MA1719.2.20 / MA1719.2.5 / MA1719.2.6 / MA1719.2.7 MA1719.2.4 MA1719.2.8 |
| Publications: | Imbeault M, Helleboid PY, Trono D. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. Nature 543:550-554 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.