Transcription Factor
| Accessions: | ESR1_DBD (HumanTF 1.0) |
| Names: | ER, ER-alpha, ESR1, ESR1_HUMAN, Estradiol receptor, Estrogen receptor, Nuclear receptor subfamily 3 group A member 1 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Uniprot: | P03372 |
| Notes: | Ensembl ID: ENSG00000091831; DNA-binding domain sequence; TF family: Nuclear_Receptor; Clone source: Megaman |
| Length: | 651 |
| Pfam Domains: | 112-180 HMG (high mobility group) box 197-263 HMG (high mobility group) box 299-357 HMG (high mobility group) box 299-357 Domain of unknown function (DUF1898) 405-469 Domain of unknown function (DUF1898) 407-468 HMG (high mobility group) box 568-627 Domain of unknown function (DUF1898) |
| Sequence: (in bold interface residues) | 1 MNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAF 60 61 KDFSGDMCKLKWVEISNEVRKFRTLTELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYF 120 121 RFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERNLARFR 180 181 EDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDATTKEVKDSLGKQWSQLSDK 240 241 KRLKWIHKALEQRKEYEEIMRDYIQKHPELNISEEGITKSTLTKAERQLKDKFDGRPTKP 300 301 PPNSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYEVELLR 360 361 FLESLPEEEQQRVLGEEKMLNINKKQATSPASKKPAQEGGKGGSEKPKRPVSAMFIFSEE 420 421 KRRQLQEERPELSESELTRLLARMWNDLSEKKKAKYKAREAALKAQSERKPGGEREERGK 480 481 LPESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKR 540 541 YERELSEMRAPPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEI 600 601 GSRWQRISQSQKEHYKKLAEEQQKQYKVHLDLWVKSLSPQDRAAYKEYISN |
| Interface Residues: | 114, 117, 119, 120, 123, 127, 139, 140, 143, 201, 206, 207, 210, 214, 222, 223, 226, 409, 412, 414, 415, 418, 422, 433, 434, 435, 438, 474, 477, 487, 505, 509 |
| 3D-footprint Homologues: | 3tmm_A, 3tq6_B, 6jrp_D, 2lef_A, 3u2b_C, 1o4x_B, 7m5w_A, 3f27_D, 4s2q_D, 1qrv_A, 4y60_C, 2gzk_A, 1j5n_A, 1hry_A, 1ckt_A |
| Binding Motifs: | ESR1_DBD arGGTCAcsrTGACCTk |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.