Transcription Factor

						

			
Accessions: 6n61_F (3D-footprint 20231221)

			
Names: Q0P6L9_ECOLX, RNA polymerase sigma factor RpoD, Sigma-70
Organisms: Escherichia coli
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q0P6L9
Length: 395
Pfam Domains:      2-33 Sigma-70 factor, region 1.2
   44-130 Sigma-70, non-essential region
  161-231 Sigma-70 region 2 
  240-316 Sigma-70 region 3
  329-382 Sigma-70, region 4
Sequence: 
(in bold interface residues)		   1 TTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEVPKQFDYLVNSMRVMMD   60
  61 RVRTQERLIMKLCVEQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVH  120
 121 RALQKLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNRG  180
 181 LQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIE  240
 241 TINKLNRISRQMLQEMGREPTPEELAERMLMPEDKIRKVLKIAKEPISMETPIGDDEDSH  300
 301 LGDFIEDTTLELPLDSATTESLRAATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGK  360
 361 QFDVTRERIRQIEAKALRKLRHPSRSEVLRSFLDD
Interface Residues: 355, 356, 365, 366, 367, 368, 370, 371
3D-footprint Homologues: 3n97_A, 6ido_B, 8cyf_B
Binding Motifs: 6n61_F GGTTT
Binding Sites: 6n61_N
6n61_T
			
Publications: Braffman NR, Piscotta FJ, Hauver J, Campbell EA, Link AJ, Darst SA. Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. Proc Natl Acad Sci U S A 116:1273-1278 (2019). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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