Transcription Factor
| Accessions: | NR2E3_MOUSE (HOCOMOCO 10), Q9QXZ7 (JASPAR 2024) |
| Names: | NR2E3_MOUSE, Nuclear receptor subfamily 2 group E member 3, Photoreceptor-specific nuclear receptor, Retina-specific nuclear receptor |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 395 |
| Pfam Domains: | 39-107 Zinc finger, C4 type (two domains) 201-379 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MSSTVAASTMPVSVAASKKESPGRWGLGEDPTGVGPSLQCRVCGDSSSGKHYGIYACNGC 60 61 SGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSM 120 121 AQVHLDAMETGSDPRSEPVVASPALAGPSPRGPTSVSATRAMGHHFMASLITAETCAKLE 180 181 PEDAEENIDVTSNDPEFPASPCSLDGIHETSARLLFMAVKWAKNLPVFSNLPFRDQVILL 240 241 EEAWNELFLLGAIQWSLPLDSCPLLAPPEASGSSQGRLALASAETRFLQETISRFRALAV 300 301 DPTEFACLKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLL 360 361 PSLRFLTAERIELLFFRKTIGNTPMEKLLCDMFKN |
| Interface Residues: | 48, 49, 51, 52, 58, 59, 61, 62, 65, 66, 91, 113, 115, 117, 149, 151, 288, 289, 290, 293, 294, 300, 304 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1lo1_A, 1a6y_A, 4oln_B, 2han_A, 1kb2_B, 1dsz_A, 8hbm_B, 5krb_G, 2han_B, 1lat_A, 2a66_A, 2nll_B, 7xv6_B, 2ff0_A, 1hcq_E, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 1e3o_C, 1o4x_A |
| Binding Motifs: | NR2E3_MOUSE.H10MO.C|M01261 aAAGTCAAAArtCA MA0164.1 cAAGCTT MA0164.2 AAGCTT |
| Binding Sites: | MA0164.1.1 / MA0164.1.16 / MA0164.1.8 MA0164.1.10 MA0164.1.11 MA0164.1.12 / MA0164.1.20 / MA0164.1.9 MA0164.1.13 / MA0164.1.7 MA0164.1.14 MA0164.1.15 MA0164.1.17 MA0164.1.18 MA0164.1.19 MA0164.1.2 MA0164.1.3 MA0164.1.4 MA0164.1.5 MA0164.1.6 MA0164.2.1 / MA0164.2.10 / MA0164.2.13 / MA0164.2.16 / MA0164.2.17 / MA0164.2.8 / MA0164.2.9 MA0164.2.11 / MA0164.2.12 / MA0164.2.4 / MA0164.2.7 MA0164.2.14 / MA0164.2.15 / MA0164.2.3 MA0164.2.18 / MA0164.2.19 / MA0164.2.2 / MA0164.2.5 / MA0164.2.6 MA0164.2.20 |
| Publications: | Chen J, Rattner A, Nathans J. The rod photoreceptor-specific nuclear receptor Nr2e3 represses transcription of multiple cone-specific genes. The Journal of neuroscience : the official journal of the Society for Neuroscience 25:118-29 (2005). [Pubmed] |
| Related annotations: | PaperBLAST |
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