Transcription Factor
| Accessions: | Q6P9A3 (JASPAR 2024) |
| Names: | ZN549_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q6P9A3 |
| Length: | 640 |
| Pfam Domains: | 27-67 KRAB box 263-286 Zinc-finger double domain 275-298 Zinc finger, C2H2 type 275-298 C2H2-type zinc finger 275-295 C2H2-type zinc finger 304-326 Zinc finger, C2H2 type 304-327 C2H2-type zinc finger 318-343 Zinc-finger double domain 332-352 C2H2-type zinc finger 332-355 Zinc finger, C2H2 type 332-355 C2H2-type zinc finger 350-371 Zinc-finger double domain 361-383 Zinc finger, C2H2 type 361-383 C2H2-type zinc finger 378-398 Zinc-finger double domain 389-407 C2H2-type zinc finger 389-411 Zinc finger, C2H2 type 404-427 Zinc-finger double domain 416-426 C2H2-type zinc finger 417-439 Zinc finger, C2H2 type 432-454 Zinc-finger double domain 445-467 C2H2-type zinc finger 445-467 Zinc finger, C2H2 type 460-482 Zinc-finger double domain 473-494 C2H2-type zinc finger 473-495 Zinc finger, C2H2 type 488-511 Zinc-finger double domain 500-510 C2H2-type zinc finger 501-523 Zinc finger, C2H2 type 516-540 Zinc-finger double domain 530-551 C2H2-type zinc finger 530-551 C2H2-type zinc finger 530-551 Zinc finger, C2H2 type 544-568 Zinc-finger double domain 558-579 C2H2-type zinc finger 558-580 C2H2-type zinc finger 558-579 Zinc finger, C2H2 type 572-594 Zinc-finger double domain 600-623 Zinc-finger double domain 612-635 C2H2-type zinc finger 613-635 C2H2-type zinc finger 613-635 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MAEAALVITPQIPMVTEEFVKPSQGHVTFEDIAVYFSQEEWGLLDEAQRCLYHDVMLENF 60 61 SLMASVGCLHGIEAEEAPSEQTLSAQGVSQARTPKLGPSIPNAHSCEMCILVMKDILYLS 120 121 EHQGTLPWQKPYTSVASGKWFSFGSNLQQHQNQDSGEKHIRKEESSALLLNSCKIPLSDN 180 181 LFPCKDVEKDFPTILGLLQHQTTHSRQEYAHRSRETFQQRRYKCEQVFNEKVHVTEHQRV 240 241 HTGEKAYKRREYGKSLNSKYLFVEHQRTHNAEKPYVCNICGKSFLHKQTLVGHQQRIHTR 300 301 ERSYVCIECGKSLSSKYSLVEHQRTHNGEKPYVCNVCGKSFRHKQTFVGHQQRIHTGERP 360 361 YVCMECGKSFIHSYDRIRHQRVHTGEGAYQCSECGKSFIYKQSLLDHHRIHTGERPYECK 420 421 ECGKAFIHKKRLLEHQRIHTGEKPYVCIICGKSFIRSSDYMRHQRIHTGERAYECSDCGK 480 481 AFISKQTLLKHHKIHTRERPYECSECGKGFYLEVKLLQHQRIHTREQLCECNECGKVFSH 540 541 QKRLLEHQKVHTGEKPCECSECGKCFRHRTSLIQHQKVHSGERPYNCTACEKAFIYKNKL 600 601 VEHQRIHTGEKPYECGKCGKAFNKRYSLVRHQKVHITEEP |
| Interface Residues: | 314, 317, 321, 343, 349, 372, 374, 375, 376, 378, 382, 389, 399, 400, 401, 402, 403, 405, 406, 408, 409, 410, 412, 427, 428, 429, 430, 431, 434, 438, 455, 456, 457, 458, 459, 461, 462, 463, 465, 484, 485, 486, 487, 488, 489, 490, 491, 511, 512, 514, 515, 518, 522, 525, 540, 542, 543, 546, 552, 566, 567, 568, 569, 570, 571, 574, 578, 595, 596, 597, 598, 599, 600, 601, 602, 623, 624, 625, 626, 627, 629, 630 |
| 3D-footprint Homologues: | 8cuc_F, 1ubd_C, 5kkq_D, 5ei9_F, 7w1m_H, 2i13_A, 6wmi_A, 2kmk_A, 6jnm_A, 6blw_A, 1mey_C, 8ssq_A, 2gli_A, 1tf6_A, 6ml4_A, 4x9j_A, 7eyi_G, 6e94_A, 7ysf_A, 2jpa_A, 7y3l_A, 6u9q_A, 5kl3_A, 1f2i_J, 5k5i_A, 1g2f_F, 8ssu_A, 5v3j_F, 1llm_D, 7y3m_I, 2drp_D, 5und_A, 4m9v_C, 2lt7_A, 5yj3_D, 5yel_A, 3uk3_C, 1tf3_A, 7n5w_A, 8h9h_G, 6a57_A, 2wbs_A, 7txc_E, 5k5l_F, 8gn3_A |
| Binding Motifs: | MA1728.1 / UN0334.1 rsTGCTGCCCwr MA1728.2 TGCTGCCC |
| Binding Sites: | MA1728.1.1 / UN0334.1.1 MA1728.1.10 / UN0334.1.10 MA1728.1.11 / UN0334.1.11 MA1728.1.12 / UN0334.1.12 MA1728.1.13 / UN0334.1.13 MA1728.1.14 / UN0334.1.14 MA1728.1.15 / UN0334.1.15 MA1728.1.16 / UN0334.1.16 MA1728.1.17 / UN0334.1.17 MA1728.1.18 / UN0334.1.18 MA1728.1.19 / UN0334.1.19 MA1728.1.2 / UN0334.1.2 UN0334.1.20 MA1728.1.4 / UN0334.1.3 MA1728.1.5 / UN0334.1.4 UN0334.1.5 MA1728.1.6 / UN0334.1.6 MA1728.1.7 / UN0334.1.7 MA1728.1.8 / UN0334.1.8 MA1728.1.9 / UN0334.1.9 MA1728.1.20 MA1728.1.3 MA1728.2.1 / MA1728.2.10 MA1728.2.11 / MA1728.2.8 MA1728.2.12 / MA1728.2.7 MA1728.2.13 MA1728.2.14 / MA1728.2.4 MA1728.2.15 MA1728.2.16 / MA1728.2.20 MA1728.2.17 / MA1728.2.19 MA1728.2.18 MA1728.2.2 MA1728.2.3 MA1728.2.5 MA1728.2.6 MA1728.2.9 |
| Publications: | Schmitges FW, Radovani E, Najafabadi HS, Barazandeh M, Campitelli LF, Yin Y, Jolma A, Zhong G, Guo H, Kanagalingam T, Dai WF, Taipale J, Emili A, Greenblatt JF, Hughes TR. Multiparameter functional diversity of human C2H2 zinc finger proteins. Genome Res 26:1742-1752 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.