Transcription Factor

						

			
Accessions: 1bdi_A (3D-footprint 20231221), 1pnr_A (3D-footprint 20231221), 1qp0_A (3D-footprint 20231221), 1qp4_A (3D-footprint 20231221), 1wet_A (3D-footprint 20231221), 1zay_A (3D-footprint 20231221)

			
Names: HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor, PURINE REPRESSOR, PURR_ECOLI
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P0ACP7
Length: 338
Pfam Domains:      1-46 Bacterial regulatory proteins, lacI family
   58-323 Periplasmic binding proteins and sugar binding domain of LacI family
   60-306 Periplasmic binding protein domain
  169-329 Periplasmic binding protein-like domain
Sequence: 
(in bold interface residues)		   1 TIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSI   60
  61 GLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVM  120
 121 CSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIG  180
 181 VIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTA  240
 241 VFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAF  300
 301 NMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR
Interface Residues: 2, 3, 12, 13, 14, 15, 17, 18, 24, 25, 26, 49, 52, 53
3D-footprint Homologues: 1efa_B, 3oqm_C, 7ce1_D, 1l1m_B, 1zvv_A, 1jft_A
Binding Motifs: 1zay_A CGAanAT
1pnr_A CGAanACg
1bdi_A CGCanACg
1qp0_A CGCancCG
1qp4_A CGCnnTCG
1wet_A CGAanACg
Binding Sites: 1bdi_B
1pnr_B / 1wet_B
1qp0_M
1qp4_M
1zay_M
			
Publications: Schumacher M.A, Choi K.Y, Zalkin H, Brennan R.G. Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. Science (New York, N.Y.) 266:763-70 (1994). [Pubmed]


Glasfeld A, Koehler A.N, Schumacher M.A, Brennan R.G. The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. Journal of molecular biology 291:347-61 (1999). [Pubmed]


Schumacher M.A, Glasfeld A, Zalkin H, Brennan R.G. The X-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water-mediated hydrogen bond to corepressor specificity and binding affinity. The Journal of biological chemistry 272:22648-53 (1997). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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