Transcription Factor

Accessions: 2r5z_A (3D-footprint 20231221)
Names: Homeotic protein Sex combs reduced, SCR_DROME
Organisms: Drosophila melanogaster
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P09077
Length: 75
Pfam Domains: 17-72 Homeobox domain
Sequence:
(in bold interface residues)
1 KKNPPQIYPWMKRVHLRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALSLTERQIK 60
61 IWFQNRRMKWKKEHK
Interface Residues: 8, 12, 13, 14, 15, 17, 18, 19, 20, 22, 24, 26, 57, 58, 60, 61, 64, 65, 68, 69, 72
3D-footprint Homologues: 6x1j_A, 4cyc_A, 1nk2_P, 1zq3_P, 1jgg_B, 3lnq_A, 2lkx_A, 6m3d_C, 2ld5_A, 5flv_I, 3d1n_M, 2hos_A, 1b72_A, 5zjt_E, 1ig7_A, 5hod_A, 6a8r_A, 3a01_E, 2h1k_B, 7psx_B, 5jlw_D, 1puf_A, 6es3_K, 4xrs_G, 3cmy_A, 2hdd_A, 7q3o_C, 1au7_A, 5zfz_A, 3rkq_B, 2r5y_A, 1fjl_B, 7xrc_C, 2xsd_C, 1e3o_C, 1le8_A, 3l1p_A, 1o4x_A, 8g87_X, 1du0_A, 4qtr_D, 1puf_B
Binding Motifs: 2r5z_AB AGATTAATcGG
Publications: Joshi R, Passner J.M, Rohs R, Jain R, Sosinsky A, Crickmore M.A, Jacob V, Aggarwal A.K, Honig B, Mann R.S. Functional specificity of a Hox protein mediated by the recognition of minor groove structure. Cell 131:530-43 (2007). [Pubmed]
Related annotations: PaperBLAST

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