Transcription Factor

						

			
Accessions: 3iag_C (3D-footprint 20231221), 6dks_G (3D-footprint 20231221)

			
Names: J kappa-recombination signal-binding protein, RBP-J kappa, Recombining binding protein suppressor of hairless, SUH_MOUSE
Organisms: Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P31266
Length: 422
Pfam Domains:    21-152 LAG1, DNA binding
  153-302 Beta-trefoil DNA-binding domain
  330-418 IPT/TIG domain
Sequence: 
(in bold interface residues)		   1 PPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGSGWKKKKEQ   60
  61 MERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMF  120
 121 YGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVE  180
 181 GGNFHASSQQWGAFYIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRK  240
 241 VDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEQNKEMINDGA  300
 301 SWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWF  360
 361 GDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGVIYSTSLTFTYTP  420
 421 EP
Interface Residues: 34, 37, 39, 139, 140, 143, 168, 169, 170
3D-footprint Homologues: 5e24_E, 3brd_A, 3iag_C
Binding Motifs: 3iag_C TCaCAyG
6dks_G tTncCA
Binding Sites: 6dks_F
6dks_E
3iag_A
3iag_B
			
Publications: Friedmann D.R, Kovall R.A. Thermodynamic and structural insights into CSL-DNA complexes. Protein science : a publication of the Protein Society 19:34-46 (2010). [Pubmed]


Yuan Z, VanderWielen BD, Giaimo BD, Pan L, Collins CE, Turkiewicz A, Hein K, Oswald F, Borggrefe T, Kovall RA. Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site. Cell Rep 26:845-854 (2019). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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