Transcription Factor
| Accessions: | UP00597F (UniPROBE 20160601) |
| Names: | BDE, BDSD, Homeobox protein Hox-4I, homeobox protein Hox-D13, HOX4I, HOXD13_Q325R, SPD |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox protein Hox-D13: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entir |
| Length: | 81 |
| Pfam Domains: | 15-71 Homeobox domain |
| Sequence: (in bold interface residues) | 1 VALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTI 60 61 WFRNRRVKDKKIVSKLKDTVS |
| Interface Residues: | 15, 16, 17, 18, 23, 26, 56, 57, 59, 60, 63, 64, 67, 68, 71 |
| 3D-footprint Homologues: | 6a8r_A, 1ig7_A, 5zfz_A, 3cmy_A, 2h1k_B, 1puf_A, 1fjl_B, 1nk2_P, 1zq3_P, 6m3d_C, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 2hdd_A, 1b72_A, 2r5y_A, 1puf_B, 5jlw_D, 3rkq_B, 2hos_A, 4xrs_G, 3a01_E, 1jgg_B, 4cyc_A, 5flv_I, 5zjt_E, 4gnx_Z, 7psx_B, 5hod_A, 3lnq_A, 1le8_A, 1e3o_C, 1au7_A, 4qtr_D, 1du0_A, 1o4x_A, 1k61_B |
| Binding Motifs: | UP00597F_1 tdccakmGTAyAAAAkwhawwr UP00597F_2 yksaakmGTAYAAAAtwmawwv |
| Binding Sites: | TAATAAAA AATAAAAA AATAAAAT ATTTATTA CGATAAAA CTAATAAA GTAATAAA TATTAATA TGTACAAA AGTATAAA ATATAAAA ATTTATAC ATTTTATA CGTATAAA GGTACAAA GGTATAAA GTACAAAA GTACAAAC GTATAAAA GTATAAAC GTTTTATA TATAAAAA TGTATAAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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