Transcription Factor
| Accessions: | UP00191A (UniPROBE 20160601) |
| Names: | class 2, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, MGC124154, MGC124155, MGC124156, Oct-2, Oct2, Oct2a, Oct2b, Octamer-binding transcription factor 2, Otf-2, Otf2, POU domain, Pou2f2, transcription factor 2 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q00196 |
| Description: | POU domain, class 2, transcription factor 2 |
| Length: | 195 |
| Pfam Domains: | 17-90 Pou domain - N-terminal to homeobox domain 119-175 Homeobox domain |
| Sequence: (in bold interface residues) | 1 SHPQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQT 60 61 TISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRK 120 121 KRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCS 180 181 AAPMLPSPGKPTSYS |
| Interface Residues: | 42, 58, 59, 60, 61, 63, 64, 70, 74, 119, 120, 121, 122, 160, 161, 163, 164, 167, 168, 171, 172, 175 |
| 3D-footprint Homologues: | 7u0g_M, 3d1n_M, 3l1p_A, 1o4x_A, 7xrc_C, 2xsd_C, 1e3o_C, 8g87_X, 1au7_A, 3cmy_A, 1ig7_A, 6a8r_A, 1puf_A, 1fjl_B, 1zq3_P, 2lkx_A, 1nk2_P, 6es3_K, 7q3o_C, 3rkq_B, 2r5y_A, 5hod_A, 3a01_E, 1b72_A, 2ld5_A, 5jlw_D, 1le8_A, 2d5v_B, 5zjt_E, 1du0_A, 6fqq_E, 5flv_I, 2h1k_B, 1jgg_B, 4cyc_A, 7psx_B, 4qtr_D, 3lnq_A, 6fqp_B, 4xrs_G |
| Binding Motifs: | UP00191A_1 ywkTATGCWAATkara |
| Binding Sites: | AATAATTA AATTAATT ACTAATTA ATAATGAG ATAATTAA ATAATTAG ATTAATTA ATTATGCA ATTTAAAT CATAATTA CCTCATTA CTAATTAA CTAATTAG CTCATTAA CTTAATTA GCTAATTA GTTAATTA TAATTAAA TATGCAAA TTAATTAA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.