Transcription Factor

						

			
Accessions: IRX5_DBD (HumanTF 1.0)

			
Names: Homeodomain protein IRX-2A, Homeodomain protein IRXB2, Iroquois homeobox protein 5, Iroquois-class homeodomain protein IRX-5, IRX5, IRX5_HUMAN
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: P78411
Notes: Ensembl ID: ENSG00000176842; DNA-binding domain sequence; TF family: homeodomain; Clone source: Megaman
Length: 112
Pfam Domains:     25-81 Homeobox domain
    39-78 Homeobox KN domain
Sequence: 
(in bold interface residues)		   1 MAGSLGYHPYAAPLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAII   60
  61 TKMTLTQVSTWFANARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEP
Interface Residues: 22, 24, 25, 28, 32, 66, 67, 69, 70, 73, 74, 75, 77, 78, 80, 81
3D-footprint Homologues: 3d1n_M, 1jgg_B, 4cyc_A, 5jlw_D, 1ig7_A, 2r5y_A, 1puf_B, 2h1k_B, 2ld5_A, 7xrc_C, 1du0_A, 5flv_I, 3a01_E, 2d5v_B, 1k61_B, 6fqp_B, 1o4x_A, 1fjl_B, 3cmy_A, 1le8_B, 6fqq_E, 4xrm_B, 2lkx_A, 1puf_A, 5zfz_A, 2hdd_A, 1mnm_C, 1b72_A, 7psx_B, 4xrs_G, 5zjt_E, 3rkq_B, 1nk2_P, 2hos_A
Binding Motifs: IRX5_DBD twACAyrACAwg
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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