Transcription Factor

Accessions: 5yj3_C (3D-footprint 20231221)
Names: hKR3, Krueppel-related zinc finger protein 3, Telomere zinc finger-associated protein, TZAP_HUMAN, Zinc finger and BTB domain-containing protein 48, Zinc finger protein 855
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 70
Pfam Domains: 3-21 Zinc-finger of C2H2 type
3-24 Zinc finger, C2H2 type
3-24 C2H2 type zinc-finger (2 copies)
4-24 C2H2-type zinc finger
17-41 Zinc-finger double domain
28-53 C2H2 type zinc-finger (2 copies)
30-50 Zinc-finger of C2H2 type
30-52 C2H2-type zinc finger
30-52 Zinc finger, C2H2 type
Sequence:
(in bold interface residues)
1 PHFCQICGKTFKAVEQLRVHVRRHKGVRKFECTECGYKFTRQAHLRRHMEIHDRVENYNP 60
61 RQRKLRNLII
Interface Residues: 12, 13, 14, 15, 16, 17, 18, 19, 20, 40, 41, 42, 43, 44, 45, 46, 47, 48, 51, 63, 66
3D-footprint Homologues: 5ei9_F, 7w1m_H, 3uk3_C, 8cuc_F, 1tf3_A, 7y3l_A, 1g2f_F, 5yel_A, 4x9j_A, 2i13_A, 8gn3_A, 1llm_D, 7txc_E, 5kl3_A, 2wbs_A, 1ubd_C, 2jpa_A, 8h9h_G, 1mey_C, 6jnm_A, 5und_A, 2drp_D, 1f2i_J, 6a57_A, 5k5i_A, 2kmk_A, 8ssq_A, 6ml4_A, 2gli_A, 7n5w_A, 6blw_A, 5kkq_D, 2lt7_A, 8ssu_A, 1tf6_A, 6u9q_A, 4m9v_C, 6e94_A, 7ysf_A, 6wmi_A, 7eyi_G, 8gh6_A, 7y3m_I, 5yj3_D, 5v3j_F
Binding Motifs: 5yj3_CD tTAGGGtTAG
Publications: Zhao Y, Zhang G, He C, Mei Y, Shi Y, Li F. The 11th C2H2 zinc finger and an adjacent C-terminal arm are responsible for TZAP recognition of telomeric DNA. Cell Res 28:130-134 (2018). [Pubmed]
Related annotations: PaperBLAST

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