Transcription Factor

						

			
Accessions: VSX1 (SMILE-seq 1.0)

			
Names: Homeodomain protein RINX, Retinal inner nuclear layer homeobox protein, Transcription factor VSX1, Visual system homeobox 1, VSX1, VSX1_HUMAN
Organisms: Homo sapiens
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: Q9NZR4
Notes: TF family: homeobox
Length: 364
Pfam Domains:   165-221 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MTGRDSLSDGRTSSRALVPGGSPRGSRPRGFAITDLLGLEAELPAPAGPGQGSGCEGPAV   60
  61 APCPGPGLDGSSLARGALPLGLGLLCGFGTQPPAAARAPCLLLADVPFLPPRGPEPAAPL  120
 121 APSRPPPALGRQKRSDSVSTSDEDSQSEDRNDLKASPTLGKRKKRRHRTVFTAHQLEELE  180
 181 KAFSEAHYPDVYAREMLAVKTELPEDRIQVWFQNRRAKWRKREKRWGGSSVMAEYGLYGA  240
 241 MVRHCIPLPDSVLNSAEGGLLGSCAPWLLGMHKKSMGMIRKPGSEDKLAGLWGSDHFKEG  300
 301 SSQSESGSQRGSDKVSPENGLEDVAIDLSSSARQETKKVHPGAGAQGGSNSTALEGPQPG  360
 361 KVGA
Interface Residues: 165, 166, 167, 168, 206, 207, 209, 210, 213, 214, 216, 217, 218, 221
3D-footprint Homologues: 8ejp_B, 8pmf_A, 6m3d_C, 1zq3_P, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 9b8u_A, 8ik5_C, 7psx_B, 2hdd_A, 4cyc_A, 8osb_E, 2hos_A, 8eml_B, 7xrc_C, 8g87_X, 8bx1_A
Binding Motifs: VSX1 rgCTAATTAr
			
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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