Transcription Factor
| Accessions: | UP00008A (UniPROBE 20160601), UP00388A (UniPROBE 20160601) |
| Names: | Homeobox protein SIX6, Optic homeobox 2, Optx2, Sine oculis homeobox homolog 6, sine oculis-related homeobox 6 homolog (Drosophila), Six6, Six9, Six9 protein |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q9QZ28 |
| Description: | sine oculis-related homeobox 6 homolog (Drosophila) |
| Length: | 92 |
| Pfam Domains: | 20-71 Homeobox domain 35-69 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 RVRKKFPLPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVG 60 61 NWFKNRRQRDRAAAAKNRLQQQVLSQGPGRVL |
| Interface Residues: | 10, 18, 19, 20, 21, 57, 58, 60, 61, 64, 65, 68, 69, 71, 72 |
| 3D-footprint Homologues: | 2d5v_B, 4xrs_G, 2lkx_A, 2r5y_A, 3l1p_A, 1le8_B, 1k61_B, 1mnm_C, 5jlw_D, 2ld5_A, 1ig7_A, 2xsd_C, 4j19_B, 1e3o_C, 7q3o_C, 1au7_A, 2h8r_B, 7xrc_C, 1le8_A, 2hdd_A, 1o4x_A, 4cyc_A, 8g87_X, 6es3_K, 1du0_A, 1puf_A, 7psx_B, 1jgg_B, 5zfz_A, 3a01_E, 2h1k_B, 6fqp_B, 5flv_I, 3lnq_A, 1puf_B, 5zjt_E, 4qtr_D, 3cmy_A, 1nk2_P, 6fqq_E, 1fjl_B, 5hod_A, 3rkq_B, 1zq3_P, 6a8r_A, 1b72_A, 4xrm_B, 3d1n_M, 6m3d_C |
| Binding Motifs: | UP00008A_1 rwwrGGGTATCAhwtwt UP00388A_1 datrGGGTATCAhwwwt UP00008A_2 mwbskATATATmcryyt UP00388A_2 rwwrGGGTATCAwtwyt |
| Binding Sites: | AAGATATC AATGATAC AGATATCA AGGTATCA AGTATCAT AGTGATAC ATGATACC ATGATATC ATTGATAC CTGATATC GATACCCC GATATATC GATATCAA GATATCAC GATATCCC GGATATCA GGTATCAA GGTATCAC TGATATCA GATATCGC |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.