Transcription Factor

						

			
Accessions: 4y5w_C (3D-footprint 20231221)

			
Names: IL-4 Stat, Signal transducer and activator of transcription 6, STAT6_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P42226
Length: 464
Pfam Domains:     24-96 STAT protein, all-alpha domain
  116-347 STAT protein, DNA binding domain
  358-432 SH2 domain
Sequence: 
(in bold interface residues)		   1 KFKTGLRRLQHRVGEIHLLREALQKEALAMLLQETTGELEAAKALVLKRIQIWKRQQQLA   60
  61 GNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGTRASLTGRLDEVLRTLVTSCFLVEK  120
 121 QPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARETGEIINNTVPLENS  180
 181 IPGNCCSALFKNLLLKKIKRCSVTEEKCAVLFSASFTLGPIQLQALSLPLVVIVHGNQDN  240
 241 NAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQK  300
 301 IFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIG  360
 361 FISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIGSPQIENIQPFSAKDLSIRSLGD  420
 421 RIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGGRGVPATIKMTVE
Interface Residues: 127, 234, 235, 236, 237, 238
3D-footprint Homologues: 1bf5_A, 1bg1_A, 4y5w_B
Binding Motifs: 4y5w_AC CCnnGGAAnnnnnA
Binding Sites: 4y5w_M
4y5w_N
			
Publications: Li J, Rodriguez JP, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S. Structural basis for DNA recognition by STAT6. Proc Natl Acad Sci U S A 113:13015-13020 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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