Transcription Factor
| Accessions: | T161901_1.02 (CISBP 1.02), UP00495A (UniPROBE 20160601), Q05958 (JASPAR 2024) |
| Names: | ECM22, T161901_1.02;, Extracellular matrix protein 22, Sterol regulatory element-binding protein ECM22, YLR228C, ECM22_YEAST, Extracellular mutant protein 22 |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription |
| Notes: | experiment type:PBM, family:Zinc cluster |
| Length: | 814 |
| Pfam Domains: | 42-80 Fungal Zn(2)-Cys(6) binuclear cluster domain 508-634 Fungal specific transcription factor domain |
| Sequence: (in bold interface residues) | 1 MTSDDGNAGQEREKDAELIEVGGKKVSKTSTGKRKFHNKSKTGCDNCKRRRVKCDEGKPF 60 61 CKKCTNMKLDCVYSPIQPRRRKDSSSSKFASAVHDRVGKKNLSDNAIMLQQQQQQLHHQQ 120 121 EQQFRQQQQVQLQQQLLPHVGTDEQSNSPNSVPPSVSNNMENLLLPHLLASLVNNTSNST 180 181 NSSANGAEAHNNITQTAPSSMINNNHPNMALPGNSPLSIPITPSFQSTAMNLSSSLNGLL 240 241 SPGRLNSVTNGLQQPQLQQQNQQIPQQQGTQSPFSNIPFDQLAQLNKMGLNFNMKSFNTL 300 301 FPYGAANGMASEFQELFGLGKFATSNNRAIKVSTAEEALANMQQEQEDKNKQFTKNPLDN 360 361 TKTDAVNSGNNPLNGNENKVTASDILSHNKNLIIDNTGLTISPPHTLSKPSIDQNIASPS 420 421 TGVSNVTSTKSLLSIPDNRTALGNSPTLKTSPMGDLLSNSEALSPRSSNSHTQQQSSPHS 480 481 NASSASRLVPELVGLSRKSNLNLIDLKLFHHYCTDVWHTITEAGISGPEVWSTYIPDLAF 540 541 HFPFLMHTILAFSATHLSRTEAGLDNYVSSHRLEALRLLREAVLEISDDNTDALVASALI 600 601 LILDSLANASSSSPTAWIFHVKGAVTILTAVWPLSETSKFYNLISVDLSDLGEAVINQSN 660 661 HNNDNDNSNNGDGNNNNTISELVCFDESIADLYPVEIDSPYLITLAYLDKLHREKNQLDF 720 721 MLRVFSFPALLDRTFLALLMTGDLGAMRIMRSYYTLLRGYTTEIKDKVWFLDSVSQVLPQ 780 781 DVDEYSGGGGMHMMLDFLGGGLPSMTTTNFSAFM |
| Interface Residues: | 39, 50, 51, 52, 75, 79, 81, 83, 84 |
| 3D-footprint Homologues: | 6o19_A, 1hwt_C, 1pyi_A, 2er8_C, 7uik_T, 3coq_A, 6gys_C, 1zme_D, 1d66_B |
| Binding Motifs: | M1808_1.02 wwwyyCsGas UP00495A_1 / UP00495A_2 gwcyascCTCGTWTAahywwsr UP00495A_3 AGGwACGA MA0292.1 hTCCGGA MA0292.2 TCCGGA |
| Binding Sites: | GGTACGAC GTCGTTTA AGGAACGA AGGTACGA CGGAACGA CGGTACGA CTAAACGA CTATACGA CTCGTACC CTCGTATA CTCGTTCC CTCGTTTA GGAACGAC GGGAACGA GGGTACGA GTATACGA GTCGTATA TATACGAA TCGTATAA TCGTTTAA |
| Publications: | Gordân R, Murphy KF, McCord RP, Zhu C, Vedenko A, Bulyk ML. Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol : (2011). [Pubmed] Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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