Transcription Factor
| Accessions: | UP00521A (UniPROBE 20160601) |
| Names: | FOXN2, HTLF, Human T-cell leukemia virus enhancer factor |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Length: | 127 |
| Pfam Domains: | 16-104 Fork head domain |
| Sequence: (in bold interface residues) | 1 GPACYQNPEKKSATSKPPYSFSLLIYMAIEHSPNKCLPVKEIYSWILDHFPYFATAPTGW 60 61 KNSVRHNLSLNKCFQKVERSHGKVNGKGSLWCVDPEYKPNLIQALKKQPFSSASSQNGSL 120 121 SPHYLSS |
| Interface Residues: | 56, 59, 61, 62, 63, 65, 66, 67, 69, 70, 79, 87 |
| 3D-footprint Homologues: | 3l2c_A, 7vox_H, 2hdc_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 7yz7_A, 6el8_A, 7tdx_A, 3qrf_G |
| Binding Motifs: | UP00521A_1 dtakawsGTAAACAAwkkyrwh UP00521A_2 mrtrygAyCGCGTCmTdawwrr UP00521A_3 aawswarrkGACGCyAhwwythk UP00521A_4 gakwwyrTGTAwACAAwmywab UP00521A_5 aawsdrrtmGACGCTAwdhyamg UP00521A_6 kahkawkRTAAACAAttryryw |
| Binding Sites: | GTAAACAA ATAAACAA ATTGTTTA GACGCGTC TAAACAAA AAAGCGTC ACCGCGTC AGACGCCA AGACGCTA AGGACGCG ATAGCGTC ATCGCGTC ATGGCGTC CCGCGTCC CGACGCTA GACGCCAA GACGCTAA GACGCTAC GGACGCTA TAGCGTCA |
| Publications: | Nakagawa S, Gisselbrecht SS, Rogers JM, Hartl DL, Bulyk ML. DNA-binding specificity changes in the evolution of forkhead transcription factors. Proc Natl Acad Sci U S A 110:12349-54 (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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