Transcription Factor

						

			
Accessions: 7khc_F (3D-footprint 20231221)

			
Names: RNA polymerase sigma factor RpoD, RPOD_ECOLI, Sigma-70
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P00579
Length: 447
Pfam Domains:     23-54 Sigma-70, non-essential region
   53-183 Sigma-70, non-essential region
  214-284 Sigma-70 region 2 
  293-369 Sigma-70 region 3
  382-435 Sigma-70, region 4
Sequence: 
(in bold interface residues)		   1 GEIDIAKRIEDGINQVQCSVAEYPEAITYLLEQYDRVEAEEARLSDLITGFVDDPELARE   60
  61 KFAELRAQYVVTRDTIKATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQER  120
 121 LIMKLCVEQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQKLQ  180
 181 QIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLI  240
 241 QEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNR  300
 301 ISRQMLQEMGREPTPEELAERMLMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIED  360
 361 TTLELPLDSATTESLRAATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRE  420
 421 RIRQIEAKALRKLRHPSRSEVLRSFLD
Interface Residues: 87, 97, 99, 100, 102, 103, 408, 409, 418, 419, 420, 421, 423, 424
3D-footprint Homologues: 3h0d_A, 3n97_A, 6ido_B, 8cyf_B
Binding Motifs: 7khc_ABF annnnnnnnnnnnnCtTGTC
Binding Sites: 7khc_X
7khc_Y
			
Publications: Shin Y, Qayyum MZ, Pupov D, Esyunina D, Kulbachinskiy A, Murakami KS. Structural basis of ribosomal RNA transcription regulation. Nat Commun 12:528 (2021). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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