Transcription Factor

						

			
Accessions: 4hn5_B (3D-footprint 20231221), 5e69_A (3D-footprint 20231221), 5e69_B (3D-footprint 20231221), 5e6a_A (3D-footprint 20231221), 5e6a_B (3D-footprint 20231221), 5e6b_B (3D-footprint 20231221)

			
Names: GCR_HUMAN, Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P04150
Length: 73
Pfam Domains:      2-70 Zinc finger, C4 type (two domains)
Sequence: 
(in bold interface residues)		   1 PKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACR   60
  61 YRKCLQAGMNLEA
Interface Residues: 12, 13, 15, 16, 22, 23, 25, 26, 29, 30, 54
3D-footprint Homologues: 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B
Binding Motifs: 5e6b_AB CGnnnAATnC
4hn5_AB CCnGnnGC
5e69_A anaTT
5e69_AB CgnnnAAtnT
5e6a_A AATnC
5e6a_AB CAnnnAATnC
Binding Sites: 4hn5_C
4hn5_D
5e69_C
5e69_D
5e6a_C
5e6a_D
5e6b_C
5e6b_D
			
Publications: Hudson W.H, Youn C, Ortlund E.A. The structural basis of direct glucocorticoid-mediated transrepression. Nature structural & molecular biology 20:53-8 (2013). [Pubmed]


Hudson WH, Vera IMS, Nwachukwu JC, Weikum ER, Herbst AG, Yang Q, Bain DL, Nettles KW, Kojetin DJ, Ortlund EA. Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements. Nat Commun 9:1337 (2018). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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