Transcription Factor
Accessions: | 4hn5_B (3D-footprint 20231221), 5e69_A (3D-footprint 20231221), 5e69_B (3D-footprint 20231221), 5e6a_A (3D-footprint 20231221), 5e6a_B (3D-footprint 20231221), 5e6b_B (3D-footprint 20231221) |
Names: | GCR_HUMAN, Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1 |
Organisms: | Homo sapiens |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | P04150 |
Length: | 73 |
Pfam Domains: | 2-70 Zinc finger, C4 type (two domains) |
Sequence: (in bold interface residues) | 1 PKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACR 60 61 YRKCLQAGMNLEA |
Interface Residues: | 12, 13, 15, 16, 22, 23, 25, 26, 29, 30, 54 |
3D-footprint Homologues: | 6fbq_A, 6l6q_B, 7wnh_D, 1lo1_A, 3g9m_B, 1a6y_A, 4oln_B, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B |
Binding Motifs: | 5e6b_AB CGnnnAATnC 4hn5_AB CCnGnnGC 5e69_A anaTT 5e69_AB CgnnnAAtnT 5e6a_A AATnC 5e6a_AB CAnnnAATnC |
Binding Sites: | 4hn5_C 4hn5_D 5e69_C 5e69_D 5e6a_C 5e6a_D 5e6b_C 5e6b_D |
Publications: | Hudson W.H, Youn C, Ortlund E.A. The structural basis of direct glucocorticoid-mediated transrepression. Nature structural & molecular biology 20:53-8 (2013). [Pubmed] Hudson WH, Vera IMS, Nwachukwu JC, Weikum ER, Herbst AG, Yang Q, Bain DL, Nettles KW, Kojetin DJ, Ortlund EA. Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements. Nat Commun 9:1337 (2018). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.