Transcription Factor
| Accessions: | CTCFL_HUMAN (HOCOMOCO 10), Q8NI51 (JASPAR 2024) |
| Names: | Brother of the regulator of imprinted sites, Cancer/testis antigen 27, CCCTC-binding factor, CT27, CTCF paralog, CTCF-like protein, CTCFL_HUMAN, Transcriptional repressor CTCFL, Zinc finger protein CTCF-T |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q8NI51 |
| Length: | 663 |
| Pfam Domains: | 257-279 C2H2-type zinc finger 272-296 Zinc-finger double domain 286-307 C2H2-type zinc finger 300-324 Zinc-finger double domain 313-336 C2H2-type zinc finger 313-336 Zinc finger, C2H2 type 328-350 Zinc-finger double domain 357-378 Zinc-finger double domain 370-392 C2H2-type zinc finger 385-408 Zinc-finger double domain 398-421 C2H2-type zinc finger 428-451 C2H2-type zinc finger 428-451 Zinc finger, C2H2 type 459-480 C2H2-type zinc finger 473-496 Zinc-finger double domain 501-524 Zinc-finger double domain 529-556 Zinc-finger double domain 546-568 Zinc finger, C2H2 type 546-567 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MAATEISVLSEQFTKIKELELMPEKGLKEEEKDGVCREKDHRSPSELEAERTSGAFQDSV 60 61 LEEEVELVLAPSEESEKYILTLQTVHFTSEAVELQDMSLLSIQQQEGVQVVVQQPGPGLL 120 121 WLEEGPRQSLQQCVAISIQQELYSPQEMEVLQFHALEENVMVASEDSKLAVSLAETTGLI 180 181 KLEEEQEKNQLLAERTKEQLFFVETMSGDERSDEIVLTVSNSNVEEQEDQPTAGQADAEK 240 241 AKSTKNQRKTKGAKGTFHCDVCMFTSSRMSSFNRHMKTHTSEKPHLCHLCLKTFRTVTLL 300 301 RNHVNTHTGTRPYKCNDCNMAFVTSGELVRHRRYKHTHEKPFKCSMCKYASVEASKLKRH 360 361 VRSHTGERPFQCCQCSYASRDTYKLKRHMRTHSGEKPYECHICHTRFTQSGTMKIHILQK 420 421 HGENVPKYQCPHCATIIARKSDLRVHMRNLHAYSAAELKCRYCSAVFHERYALIQHQKTH 480 481 KNEKRFKCKHCSYACKQERHMTAHIRTHTGEKPFTCLSCNKCFRQKQLLNAHFRKYHDAN 540 541 FIPTVYKCSKCGKGFSRWINLHRHSEKCGSGEAKSAASGKGRRTRKRKQTILKEATKGQK 600 601 EAAKGWKEAANGDEAAAEEASTTKGEQFPGEMFPVACRETTARVKEEVDEGVTCEMLLNT 660 661 MDK |
| Interface Residues: | 257, 268, 269, 270, 271, 274, 295, 296, 298, 299, 301, 302, 304, 305, 308, 323, 324, 325, 326, 327, 330, 334, 352, 353, 354, 355, 356, 358, 359, 360, 377, 379, 380, 381, 382, 383, 384, 385, 386, 387, 388, 408, 409, 410, 411, 412, 414, 415, 416, 419, 438, 439, 440, 441, 442, 445, 448, 468, 469, 471, 472, 474, 475, 481, 495, 496, 497, 498, 499, 500, 503, 507, 524, 525, 526, 527, 528, 529, 530, 531, 535, 556, 557, 559, 560, 563 |
| 3D-footprint Homologues: | 2kmk_A, 7w1m_H, 7ysf_A, 8cuc_F, 7y3l_A, 2gli_A, 2i13_A, 1llm_D, 6wmi_A, 6e94_A, 2jpa_A, 1ubd_C, 7n5w_A, 8ssu_A, 5kkq_D, 5ei9_F, 1mey_C, 5kl3_A, 1f2i_J, 5yj3_D, 8ssq_A, 7eyi_G, 8h9h_G, 1tf3_A, 5und_A, 1g2f_F, 6ml4_A, 5v3j_F, 4x9j_A, 6blw_A, 6u9q_A, 7txc_E, 4m9v_C, 1tf6_A, 2wbs_A, 3uk3_C, 5k5i_A, 2drp_D, 5yel_A, 5k5l_F, 6jnm_A, 6a57_A, 2lt7_A, 8gn3_A, 7y3m_I |
| Binding Motifs: | CTCFL_HUMAN.H10MO.A|M01069 ygrCCAsyAGrkGGCrsyv MA1102.1 CrsCAGGGGGCrsy MA1102.2 rsCAGGGGGCgs MA1102.3 CAGGGGGC |
| Binding Sites: | MA1102.3.15 MA1102.3.17 MA1102.3.3 / MA1102.3.5 / MA1102.3.8 MA1102.1.1 MA1102.1.10 MA1102.1.11 MA1102.1.12 MA1102.1.13 MA1102.1.14 MA1102.1.15 MA1102.1.16 MA1102.1.17 MA1102.1.18 MA1102.1.19 MA1102.1.2 MA1102.1.20 MA1102.1.3 MA1102.1.4 / MA1102.1.5 MA1102.1.6 MA1102.1.7 MA1102.1.8 MA1102.1.9 MA1102.2.1 / MA1102.2.2 MA1102.2.10 / MA1102.2.5 MA1102.2.11 / MA1102.2.7 MA1102.2.12 / MA1102.2.8 MA1102.2.13 / MA1102.2.9 MA1102.2.10 / MA1102.2.14 MA1102.2.15 MA1102.2.11 / MA1102.2.16 MA1102.2.12 / MA1102.2.17 MA1102.2.13 / MA1102.2.18 MA1102.2.19 MA1102.2.20 MA1102.2.3 / MA1102.2.6 / MA1102.2.7 MA1102.2.3 / MA1102.2.4 MA1102.2.5 MA1102.2.8 MA1102.2.4 / MA1102.2.9 MA1102.2.14 MA1102.2.15 MA1102.2.16 MA1102.2.17 MA1102.2.18 MA1102.2.19 MA1102.2.20 MA1102.2.6 MA1102.3.1 / MA1102.3.10 / MA1102.3.12 / MA1102.3.13 / MA1102.3.14 / MA1102.3.18 / MA1102.3.19 / MA1102.3.2 / MA1102.3.4 / MA1102.3.7 MA1102.3.11 / MA1102.3.6 MA1102.3.16 MA1102.3.20 MA1102.3.9 |
| Publications: | Pugacheva EM, Rivero-Hinojosa S, Espinoza CA, Méndez-Catalá CF, Kang S, Suzuki T, Kosaka-Suzuki N, Robinson S, Nagarajan V, Ye Z, Boukaba A, Rasko JE, Strunnikov AV, Loukinov D, Ren B, Lobanenkov VV. Comparative analyses of CTCF and BORIS occupancies uncover two distinct classes of CTCF binding genomic regions. Genome Biol : (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.