Transcription Factor
| Accessions: | UP00190A (UniPROBE 20160601) |
| Names: | Homeobox protein NK-2 homolog 3, Homeobox protein NK-2 homolog C, Homeobox protein Nkx-2.3, locus 3 (Drosophila), NK2 transcription factor related, Nkx2-3, Nkx2-C, Nkx2.3, Nkx2c, tinman |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P97334 |
| Description: | NK2 transcription factor related, locus 3 (Drosophila) |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 DCKTSEDGERPKPRSRRKPRVLFSQAQVFELERRFKQQRYLSAPEREHLASSLKLTSTQV 60 61 KIWFQNRRYKCKRQRQDKSLELGTHAPPPPPRR |
| Interface Residues: | 16, 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 5zfz_A, 4j19_B, 1ig7_A, 2h1k_B, 1puf_A, 5zjt_E, 3cmy_A, 6a8r_A, 3d1n_M, 1fjl_B, 6m3d_C, 2lkx_A, 1nk2_P, 1zq3_P, 2ld5_A, 7q3o_C, 6es3_K, 1b72_A, 4xrs_G, 3a01_E, 5flv_I, 3lnq_A, 1jgg_B, 2hdd_A, 7psx_B, 5hod_A, 3rkq_B, 2r5y_A, 1au7_A, 2hos_A, 5jlw_D, 7xrc_C, 1e3o_C, 2xsd_C, 1le8_A, 3l1p_A, 1o4x_A, 1le8_B, 1du0_A, 8g87_X, 4qtr_D, 1mnm_C, 1puf_B, 1k61_B, 4xrm_B, 4cyc_A |
| Binding Motifs: | UP00190A_1 yyTtAAGYRCTTaatg |
| Binding Sites: | AAGTGGAT ACACTTAA ACCACTTA ATAAGTGG CACTTAAA CACTTAAG CACTTATC CACTTGAA CACTTGAG CCACTTAA CCACTTAG CCACTTCA CCACTTGA CCCACTTA GCACTTAA GCACTTGA GCCACTTA GGTACTTA GTACTTAA TAAGTGGA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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