Transcription Factor

						

			
Accessions: 4yln_F (3D-footprint 20231221), 4ylo_F (3D-footprint 20231221), 4ylp_F (3D-footprint 20231221)

			
Names: RNA polymerase sigma factor RpoD, RPOD_ECOLI, Sigma-70
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P00579
Length: 497
Pfam Domains:     17-48 Sigma-70 factor, region 1.2
    59-93 Sigma-70, non-essential region
   92-232 Sigma-70, non-essential region
  263-333 Sigma-70 region 2 
  342-418 Sigma-70 region 3
  431-484 Sigma-70, region 4
Sequence: 
(in bold interface residues)		   1 AAAQVLSSVESEIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYP   60
  61 EAITYLLEQYDRVEAEEARLSDLITGFVDPNAENSIDPELAREKFAELRAQYVVTRDTIK  120
 121 AKGRSHATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQCK  180
 181 MPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQKLQQIEEETGLTIE  240
 241 QVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAV  300
 301 DKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNRISRQMLQEMGR  360
 361 EPTPEELAERMLMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSAT  420
 421 TESLRAATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIEAKALR  480
 481 KLRHPSRSEVLRSFLDD
Interface Residues: 136, 146, 148, 149, 151, 152, 457, 458, 467, 468, 469, 470, 472, 473
3D-footprint Homologues: 3h0d_A, 3n97_A, 6ido_B, 8cyf_B
Binding Motifs: 4yln_F AGGATTATAGCnnAnnnnnnnnnnGTCAa
4ylo_F AGGATTATAGCAnAnnnnnnnnnnnTGTCnnG
4ylp_F GTAGGATTATAGCATnnnnnnnnnnnnTnTCA
Binding Sites: 4ylo_1
4ylo_2
4ylp_1
4ylp_2
4yln_1
4yln_2
			
Publications: Zuo Y, Steitz T.A. Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble. Molecular cell 58:534-40 (2015). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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